gms | German Medical Science

28. Wissenschaftlicher Kongress der Deutschen Hochdruckliga

24. bis 27.11.2004, Hannover

Persistent sympathetic overactivity in renal allograft recipients

Anhaltende erhöhte sympathische Nervenaktivität bei nierentransplantierten Patienten

Meeting Abstract (Hypertonie 2004)

  • M. Hausberg - Universitätsklinikum Münster (Münster, D)
  • M. Barenbrock - Universitätsklinikum Münster (Münster, D)
  • A. Levers - Universitätsklinikum Münster (Münster, D)
  • M. Kosch - Universitätsklinikum Münster (Münster, D)

Hypertonie 2004. 28. Wissenschaftlicher Kongress der Deutschen Hochdruckliga. Hannover, 24.-27.11.2004. Düsseldorf, Köln: German Medical Science; 2005. Doc04hochP87

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter: http://www.egms.de/de/meetings/hoch2004/04hoch087.shtml

Veröffentlicht: 10. August 2005

© 2005 Hausberg et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielf&aauml;ltigt, verbreitet und &oauml;ffentlich zug&aauml;nglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

Objectives: Sympathetic overactivity is present in renal failure and contributes to hypertension and high cardiovascular morbidity in these patients. Correction of uremia by renal transplantation (RTX) does not have a short-term effect on sympathetic overactivity. However, the long-term effect of RTX on muscle sympathetic nerve activity (MSNA) and a possible effect of the type of immunosuppression has not been studied. We investigated sympathetic nerve activity 3 and 18 months after RTX in stable transplant patients treated with cyclosporine A (Rx-CYA) or tacrolimus (Rx-FK) and in normal controls.

Methods: 21 patients with stable graft function (9 Rx-CYA, 12 Rx-FK, serum creatinine 1.2+/-0.4 and 1.2+/-0.7 mg/dl, age 44+/-7 and 46+/-6, resp.) were included. MSNA was measured by microneurography at the peroneal nerve 3 and 18 months after RTX. Plasma norepinephrine (NE) levels were also studied. 22 sex- and age-matched healthy volunteers were studied as control group (serum creatinine 0.92+/-0.12 mg/dl).

Results: Data are mean+/-SD. MSNA was significantly higher in both patient groups compared to controls (19+/-11 burst/min, p<0.01 vs. Rx-CyA and Rx-FK). However, in patients elevated MSNA did not change during follow up after RTX. Neither were there significant between group- or trend-differences between Rx-CYA and Rx-FK.

Conclusions: Our data show significant and persistent sympathetic overactivity for up to 18 months after renal transplantation in patients with stable graft function independent of the type of calcineurin-inhibitor used. Moreover, our data show a good longitudinal reproducibilty of microneurographic measurements of sympathetic nerve activity, confirming the good reproducibility of this method in other patient collectives and in healthy volunteers.

Table 1 [Tab. 1]