gms | German Medical Science

28. Wissenschaftlicher Kongress der Deutschen Hochdruckliga

24. bis 27.11.2004, Hannover

Blood pressure parameters and their correlation to NT-proBNP

Blutdruck-Parameter und ihr Verhältnis zu NT-proBNP-Werten

Meeting Abstract (Hypertonie 2004)

  • presenting/speaker B. Gremmler - Marienhospital Bottrop (Bottrop, D)
  • presenting/speaker K. Kisters - St. Anna-Hospital Herne (Herne, D)
  • presenting/speaker M. Kunert - Marienhospital Bottrop (Bottrop, D)
  • presenting/speaker H. Schleiting - Marienhospital Bottrop (Bottrop, D)
  • presenting/speaker L. Ulbricht - Marienhospital Bottrop (Bottrop, D)

Hypertonie 2004. 28. Wissenschaftlicher Kongress der Deutschen Hochdruckliga. Hannover, 24.-27.11.2004. Düsseldorf, Köln: German Medical Science; 2005. Doc04hochP81

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter: http://www.egms.de/de/meetings/hoch2004/04hoch081.shtml

Veröffentlicht: 10. August 2005

© 2005 Gremmler et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielf&aauml;ltigt, verbreitet und &oauml;ffentlich zug&aauml;nglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

Background: The determination of NT-proBNP- values is increasingly used as a marker to estimate the dignity of chronic heart failure. In this context an elevated NT-proBNP-value is a sign of worse prognosis. On the other hand numerous studies have shown that increases in blood pressures are positively associated with cardiac events. Therefore we did a research on a connection between NT-proBNP-values and pulse pressure- , mean arterial pressure- , systolic and diastolic pressure- values to prove a possible correlation.

Methods: NT-proBNP-levels were analysed before left-heart catheterization in 125 patients (unselected population with exclusion of renal or valvular diseases ; 60,6 ±10,1 years). The determination of NT- proBNP in plasma was performed using the electrochemiluminescence technology in the Elecsycanalyser and the Elecsys-proBNP immunoassay (Roche-Diagnostics, Mannheim ).All arterial pressure-values (PP,MAP.SBP and DBP)were invasively measured in the aortic arch before application of contrast-medium. Finally, the NT-proBNP values were compared to the invasively measured arterial pressure-values accordingly.

Results:

1) NT-proBNP values in correlation to the pulse pressure-values : no correlation (r=0,014);

2) NT-proBNP values in correlation to systolic blood pressure : no correlation (r= 0,09) ;

3) NT-proBNP values in correlation to mean blood pressure: weak correlation (r=0,203)

4) NT-proBNP values in correlation to diastolic blood pressure: weak, however best correlation (r=0,247)

Conclusion: The best correlation of NT-proBNP-values and blood pressure parameters was found in case of the diastolic pressure values. Despite the weak correlation, this observation may an indicator to interpret the elevated diastolic blood pressure as risk factor for myocardial heart failure ,whereas - corresponding current publications -elevated pulse pressure and systolic blood pressure are predictor of vascular risks.