gms | German Medical Science

28. Wissenschaftlicher Kongress der Deutschen Hochdruckliga

24. bis 27.11.2004, Hannover

Angiotensiogen (AGT) Promoter Haplotyes are Associated With Bloot Pressure in Untreated Hypertensives

Assoziation von Angiotensinogen (AGT)-Promoter-Haplotypen mit Blutdruck bei unbehandelten Hypertonikern

Meeting Abstract (Hypertonie 2004)

  • presenting/speaker K. Schmidt-Petersen - Institut für Arterioskleroseforschung Universitätsklinikum Münster (Münster, D)
  • presenting/speaker S.-M. Brand-Herrmann - Institut für Arterioskleroseforschung Universitätsklinikum Münster (Münster, D)
  • presenting/speaker F. Reichenberger - Medizinische Klinik IV, Campus Benjamin Franklin
  • presenting/speaker K. Köpke - Medizinische Klinik IV, Campus Benjamin Franklin (Berlin, D)
  • presenting/speaker M. Paul - Institut für Klin. Pharm. und Tox. Campus Benjamin Franklin (Berlin, D)
  • presenting/speaker W. Reineke - Institut für Klin. Pharm. und Tox. Campus Benjamin Franklin (Berlin, D)
  • presenting/speaker W. Zidek - Medizinische Klinik IV, Campus Benjamin Franklin (Berlin, D)
  • presenting/speaker E. Brand - Medizinische Klinik IV, Campus Benjamin Franklin (Berlin, D)

Hypertonie 2004. 28. Wissenschaftlicher Kongress der Deutschen Hochdruckliga. Hannover, 24.-27.11.2004. Düsseldorf, Köln: German Medical Science; 2005. Doc04hochP16

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter: http://www.egms.de/de/meetings/hoch2004/04hoch016.shtml

Veröffentlicht: 10. August 2005

© 2005 Schmidt-Petersen et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielf&aauml;ltigt, verbreitet und &oauml;ffentlich zug&aauml;nglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

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Objectives: The polymorphic angiotensinogen (AGT) gene is one of the most promising candidate genes for blood pressure (BP) phenotypes and essential hypertension and some reports point to a superiority of haplotype compared to single polymorphism analysis.

Methods: We genotyped a Caucasian study population comprising hypertensive subjects (n = 704) with and without antihypertensive medication for the AGT polymorphisms C-532T, A-20C, C-18T, and G-6A and investigated whether AGT promoter haplotypes rather than AGT single variants separately were associated with various BP phenotypes available in our study population.

Results: In single variant analyses, hypertensive patients without medication, carrying the AGT -532T or -6A alleles had significantly higher SBP, DBP, as well as ambulatory BP values compared to respective non-carriers. In haplotype-based analyses, combining all four AGT promoter variants, we demonstrate that AGT haplotypes containing different allele combinations at positions -532 and -6 were significantly associated with different BP values: (1) -532T and -6A with higher, (2) -532C and -6G with lower, (3) -532C and -6A with intermediate BP values. Since the result for the -532C/-20A/-18C/-6G haplotype was due to differences between non-carriers and carriers of this haplotype on both chromosomes, a recessive inheritance model for BP effects could be assumed.

Conclusions: Our results designate the C-532T and G-6A as the best candidates for functional studies on the AGT gene. Haplotype-based analyses should greatly aid in the dissection of the genetic basis of complex traits, such as BP and hypertension.