gms | German Medical Science

27. Wissenschaftlicher Kongress der Deutschen Hochdruckliga

Deutsche Liga zur Bekämpfung des hohen Blutdrucks – Deutsche Hypertonie Gesellschaft e. V.

26. bis 29.11.2003, Bonn

Limited effects of sympathoexcitation on parameters of haemostasis in primary hypertensive subjects

Limitierte Effekte von Sympathoexzitation auf das Hämostasesystem bei primären Hypertonikern

Meeting Abstract (Hypertonie 2003)

Suche in Medline nach

  • J. Struck - Lübeck, D
  • H. Fehm - Lübeck, D
  • C. Dodt - Lübeck, D

Hypertonie 2003. 27. Wissenschaftlicher Kongress der Deutschen Hochdruckliga. Bonn, 26.-29.11.2003. Düsseldorf, Köln: German Medical Science; 2004. Doc03hochP89

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter: http://www.egms.de/de/meetings/hoch2003/03hoch189.shtml

Veröffentlicht: 11. November 2004

© 2004 Struck et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielf&aauml;ltigt, verbreitet und &oauml;ffentlich zug&aauml;nglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

Objective

To investigate the relationship between sympathetic activation and fibrinolytic activity. We tested the effects of three standardized sympathoexcitatory maneuvers on different haemostatic parameters in hypertensive subjects.

Design and methods

18 hypertensive otherwise healthy subjects without antihypertensive drugs were examined. Three consecutive sympathoexcitatory maneuvers were performed (lower body negative pressure 10 min (LBNP), cold pressor 1,5 min, hyperinsulinemic euglycemic clamp 60 min). Sympathoexcitation was quantified by microneurographic recording of muscle sympathetic nerve activity (MSNA). Additionally blood pressure and heart rate were measured. Blood was drawn to determine levels of epinephrine, norepinephrine, tissue plasminogen activator (t-PA), t-PA complexed with plasminogen activator inhibitor type 1 (t-PA/PAI), thrombin-antithrombin III complex (TAT), prothrombin fragment 1+2 (F1+2) and D-Dimer. Data are expressed as mean ± SEM.

[Tab. 1]

Results

All three sympathoexcitatory maneuvers significantly increased MSNA with no difference in effect. Only the cold pressor test exerts significant effects on t-PA and TAT.

Conclusions

Standardized maneuvers to induce sympathoexcitation of similar strength evoke differential effects on haemostasis. Significant effects were only observed during the painful cold pressor test. This suggests that sympathoexcitation per se exerts only limited effects on haemostatic parameters in vivo.