gms | German Medical Science

27. Wissenschaftlicher Kongress der Deutschen Hochdruckliga

Deutsche Liga zur Bekämpfung des hohen Blutdrucks – Deutsche Hypertonie Gesellschaft e. V.

26. bis 29.11.2003, Bonn

Reduced myocardial NGF production and decreased norepinephrine stores in human essential hypertension

Verminderte myokardiale NGF Produktion und verringerte Noradrenalin Speicher bei essentieller Hypertonie

Meeting Abstract (Hypertonie 2003)

Suche in Medline nach

  • presenting/speaker M.P. Schlaich - Erlangen, D; Melbourne, AUS
  • D. Kaye - Erlangen, D; Melbourne, AUS
  • G. Lambert - Erlangen, D; Melbourne, AUS
  • M. Esler - Erlangen, D; Melbourne, AUS

Hypertonie 2003. 27. Wissenschaftlicher Kongress der Deutschen Hochdruckliga. Bonn, 26.-29.11.2003. Düsseldorf, Köln: German Medical Science; 2004. Doc03hochP74

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter: http://www.egms.de/de/meetings/hoch2003/03hoch174.shtml

Veröffentlicht: 11. November 2004

© 2004 Schlaich et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielf&aauml;ltigt, verbreitet und &oauml;ffentlich zug&aauml;nglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

Background

Increased nerve growth factor (NGF) expression has been linked to sympathetic hyperinnervation in rat models of hypertension. Whether this might also be the case in human hypertension has not yet been investigated.

Methods and Results

Cardiac NE stores, as an index of sympathetic innervation, were measured from the rate of overflow of the NE metabolite, dihydroxyphenylglycol (DHPG), and its tritiated form into the coronary sinus (CS) during an infusion of [3H]NE in 39 hypertensive patients (EH) and 73 matched normotensive control subjects (NT), on the basis that the [3H]DHPG/DHPG concentration ratio in CS plasma is inversely proportional to vesicular NE stores in the heart. To complement these data, we also determined the transcardiac gradients for plasma NGF. Cardiac NE spillover was higher in hypertensive patients (NT: 89.5±6.6 vs EH: 142.9±14.8 pmol/min; p<0.01). However, the plasma NGF gradient across the heart (NT: 21.1±6.6 vs EH: -5.8±6.2pg/ml; p<0.05) and the size of cardiac NE stores (NT: 713±67 vs EH: 328±180 nmol; p<0.05) were substantially reduced in hypertensive patients.

Conclusions

Cardiac sympathetic activation in essential hypertension is accompanied by reduced cardiac NGF production and decreased NE stores. In contrast to animal models of hypertension, sympathetic hyperinnervation seems to be excluded in human hypertension, where the decrease in NGF production and cardiac NE stores may represent an adaptive response to increased cardiac NE release.