gms | German Medical Science

83. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e. V.

Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e. V.

16.05. - 20.05.2012, Mainz

Gene mutations detection and mutants functional analysis of Waardenburg syndrome

Meeting Abstract

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  • corresponding author Hao Wu - Xinhua Hospital Affiliated Medical College of Shanghai, Shanghai, P. R. China
  • Zhihua Zhang - Xinhua Hospital Affiliated Medical College, Shanghai, P. R. China
  • Zhaoyan Wang - Xinhua Hospital Affiliated Medical College, Shanghai, P. R. China
  • Qi Huang - Xinhua Hospital Affiliated Medical College, Shanghai, P. R. China

Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie. 83. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie. Mainz, 16.-20.05.2012. Düsseldorf: German Medical Science GMS Publishing House; 2012. Doc12hnod571

doi: 10.3205/12hnod571, urn:nbn:de:0183-12hnod5718

Veröffentlicht: 4. April 2012

© 2012 Wu et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielf&aauml;ltigt, verbreitet und &oauml;ffentlich zug&aauml;nglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

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Objective: To report postoperative functional outcomes for vestibular schwannomas (VS) in a large series.

Methods: Over a period of 10 years, 594 patients with VS were dignosed in our department. Among them, 461 patients underwent surgery via translabyrinthine, retrosigmoid, middle fossa and transchecholear approaches.

Results: Translabyrinthine(72.9%), retrosigmoid (13.7%), middle fossa (10.4%) and transchecholear (3.0%) approaches were performed in 461 cases (77.6%), which was selected by tumor size, location, hearing estimation, and patients’ age. Total, near total and patial removal rate was 95.9%, 3.0% and 1.1%, respectively. Hearing preservative approaches were attempted in 111 cases, among which 25.2% and 48.6% have good and useful hearing. Facial nerve was anatomically preserved in 435 cases (99.4%) and interrupted in 26 cases with above large tumors and/or recurrent tumors.1 patients (0.2%) died of cerebrovascular accident. Lower cranial nerve dysfunction occurred in 13 patients. CSF leakage occurred in 15 cases (3.3%). Recurrent rate was 2.2%.

Conclusions: Correct estimation of tumor in nature is of great importance in the determination of proper treatment strategy or surgical approaches. Although microsurgery is still the most available method, the ratio of “wait & scan” and SRT is increasing. The preoperative management, surgical skills, and experience play a pivotal role in complete tumor resection.Postoperative complications can be prevented and be cured by careful surgical procedures and postoperative management. Total tumor removal and VII & VIII preservation could reach a high ratio in hands of experienced surgeon.