Artikel
The expression and significance of Brg1 in vocal cord polyps precancerous lesion and laryngeal squamous cell carcinoma
Suche in Medline nach
Autoren
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Wei Zhu
- The First Hospital of JiLin University, Changchun, P.R. China
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Xin Wang
- The First Hospital of JiLin University, Changchun, P.R. China
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Xiangyan Cui
- The First Hospital of JiLin University, Changchun, P.R. China
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Weilun Chen
- The First Hospital of JiLin University, Changchun, P.R. China
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Yu Hong
- The First Hospital of JiLin University, Changchun, P.R. China
| Veröffentlicht: | 4. April 2012 |
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Gliederung
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Objective: To study the expression of Brg1 in laryngeal squamous cell carcinoma (LSCC) and its relationship with the occurrence and development of tumor.
Methods: Immunohistochemical method was used to detect the expressions of Brg1 in 30 cases of LSCC, 10 cases of normal mucosa ajacent tumor, 10 cases of vocal cord polyps and 10 cases of precancerous lesion.
Results: The expression of Brg1 in normal mucosa adjacent cancer was positive(grey value is 124.6±4.51), and the expression of Brg1 in LSCC was low(grey value is 159.2±7.69), the difference between the two groups was significant (P<0.01). In precancerous lesion, the expression of Brg1 was strong (grey value is 89.2±3.70), and the expression of Brg1 in vocal cord polyps was weak(grey value is 174.2±3.03), the difference between the two groups was significant (P<0.01). The grey value expressed by Brg1 in well, moderately and poorly LSCC were 132.8±1.92, 165.2±2.59, 179.6±1.52 respectively; moderately and poorly differentiated LSCC compared with well differentiation respectively, the difference was significant (P<0.01). The grey value expressed by Brg1 in I-II stage, III stage and IV stage were 145.3±2.36, 165.2±4.31, 179.4±3.03 respectively; III stage and IV stage compared with I-II stage respectively, the difference was significant (P<0.05). The grey value expressed by Brg1 in vascular invasion group and no vascular invasion group were 176.8 ± 3.48 and 143.5±8.26, the difference between the two groups was significant (P<0.01).
Conclusions: The expression of Brg1 in LSCC is low, and it is related to the development of cancer and pathological factors, which may be an important factor in laryngeal cancer.
