Artikel
Prognostic Relevance of Lysyl Oxidase-Expression in Oral and Oropharyngeal Squamous Cell Carcinoma (OSCC)
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Autoren
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Andrea Albinger
- ORL Klinik Zürich, Switzerland
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Ivan Hegyi
- Department of Dermatolgy, Inselspital Bern, Switzerland
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Sandro Stöckli
- Clinic of Otorhinolaryngology, Head and Neck Surgery, Kantonsspital St. Gallen, Switzerland
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Stephan Schmid
- Clinic Bethanien, Zürich, Switzerland
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Holger Moch
- Department Pathology, Institute of Surgical Pathology, University Hospital Zürich, Switzerland
| Veröffentlicht: | 22. April 2010 |
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Gliederung
Text
Introduction: Hypoxia, the inadaquate supply of blood borne oxygen, was identified as a marker of an aggressive tumour phenotype and malignant progression. Hypoxia is associated with a poor tumour response to radiotherapy, to some chemotherapeutic agents, as well as poor outcome following surgery. Pathways regulated by hypoxia include: tissue invasion, metastasis, genetic instability, apoptosis, immortalization, angiogenesis, growth factor signalling and pH regulation3.
Lysyl oxidase (LOX) is a copper-dependent metalloenzyme. Recently LOX was validated as a hypoxia-responsive gene regulated by hypoxia-inducible factor-1. Conflicting data were published so far, regarding the expression and significance of LOX in head and neck squamous cell carcinoma.
Methods: We have analysed 252 patientens: 92 with, 160 without lymph node metastases with tissue microarrays (TMA). TMA was constructed according to standard protocols.
Results: Correlation of the LOX-Expression with the clinicopathological patient characteristics.
High LOX-expression shows a significant correlation with the presence of lymph node disease (P=0.001) in the entire patient cohort, as well as for patients with small primary tumors (T1 und T2) (P=0.001).
Kaplan-Meier plot.
OSCC patients with high LOX-expression have significantly shortened overall and disease free survival (P=0.004 und P=0.038).
Conclusion: The univariate analysis revealed correlation between overall survival and the T-stadium (P=0.000), N-stadium (P=0.012),as well as the LOX-Expression (P=0.004). Tumor T-stadium (P=0.000) as well as the high LOX-expression (P=0.044) were indentified in the Cox-regression modell as independent negative prognostic factors for the overall survival.
