gms | German Medical Science

80. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e. V.

Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e. V.

20.05. - 24.05.2009, Rostock

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Brainstem auditory evoked potential (BAEP) examinations in patients with short-standing type-1 diabetes mellitus

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  • corresponding author József Géza Kiss - University of Szeged, Department of Otolaryngology, Szeged, Hungary
  • Ferenc Toth - University of Szeged, Department of Otolaryngology, Szeged, Hungary
  • Tamás T. Várkonyi - University of Szeged, 1st Department of Medicine, Szeged, Hungary
  • Laszló Rovó - University of Szeged, Department of Otolaryngology, Szeged, Hungary
  • Szabolcs Beke - University of Szeged, Department of Otolaryngology, Szeged, Hungary
  • Csaba Lengyel - University of Szeged, 1st Department of Medicine, Szeged, Hungary
  • Péter Légrády - University of Szeged, 1st Department of Medicine, Szeged, Hungary
  • József Jóri - University of Szeged, Department of Otolaryngology, Szeged, Hungary

Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie. 80. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie. Rostock, 20.-24.05.2009. Düsseldorf: German Medical Science GMS Publishing House; 2009. Doc09hnod502

doi: 10.3205/09hnod502, urn:nbn:de:0183-09hnod5028

Veröffentlicht: 17. April 2009

© 2009 Kiss et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielfältigt, verbreitet und öffentlich zugänglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.

Gliederung

Text

Introduction: Our previous results showed that diabetic neuropathy may be manifested in certain dysfunctions of the central auditory pathways. BAEP parameters of patients with long-standing (> 20 years) type-1 diabetes mellitus differed significantly compared with healthy controls. A significant correlation was observed between the overall autonomic score (AN) and the latencies (wave III and V) and IPL-s (I-III, I-V).

Methods: We performed BAEP examinations in patients with short-standing type-1 diabetes mellitus (DM). 21 insulin-treated patients with DM of shorter (0-20 years) duration were included. Cardiovascular reflex tests were applied for assessment of autonomic neuropathy. Our aim was to compare the BAEP results of this patient group with controls and to look for the possible correlation between the alteration of the auditory brainstem function and the cardiovascular autonomic and the peripheral sensory neuropathy in this earlier period of DM..

Results: Analysis of the latencies (wave I, II, III and IV/V) and the inter-peak latencies (IPL I-III: and I-IV/V) of BAEP didn’t show a significant difference between diabetics and healthy controls at 16 Hz stimulus rate. But a positive correlation was observed between the overall autonomic score (AN) and the latencies and IPL-s. Evaluation of the peripheral sensory nerve function revealed positive association current perception thresholds (CPT at 2 kHz and 250 Hz) and wave latency values (wave III and V).

Conclusions: Several parameters of autonomic and sensory neuropathy consequently worsen together with abnormalities of brainstem function. Our data support the hypothesis that diabetic neuropathy might be manifested in certain dysfunctions of the central auditory pathways in the early period of DM.