gms | German Medical Science

78. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e. V.

Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e. V.

16.05. - 20.05.2007, München

Cholesteatoma – the Neoangiogenesis in Adults and Children

Meeting Abstract

  • corresponding author Pavel Dimov - Univ.Clinic ORL, Stara Zagora, Bulgarien
  • Tatyana Vlaykova - Dept. of Biochemistry, Stara Zagora, Bulgarien
  • May Gulubova - Dept. of General and Clinical Pathology, Stara Zagora, Bulgarien
  • Georgi Edrev - Medical Faculty, Trakia University, Stara Zagora, Bulgarien
  • Anna Michova - National Transport Hospital, Sofia, Bulgarien

Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie. 78. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e.V.. München, 16.-20.05.2007. Düsseldorf: German Medical Science GMS Publishing House; 2007. Doc07hnod310

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter: http://www.egms.de/de/meetings/hnod2007/07hnod310.shtml

Veröffentlicht: 24. April 2007

© 2007 Dimov et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielf&aauml;ltigt, verbreitet und &oauml;ffentlich zug&aauml;nglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

Оbjective: The aim of the current study was: to detect the presence of large and newly form small blood vessels in chronic inflammation of cholesteatoma and to evaluate the role of VEGF and CD-31 in triggering of angiogenesis in chronic inflammation of cholesteatoma in adults and children

Material & Methods: The CD-31- positive blood vessels and the level of expression of VEGF were determined by immunohistochemistry 16 archival biopsies which from patients with adults cholesteatoma and 5 patients with pediatric cholesteatoma

Results: CD31-positive blood vessels in the granulation tissue of cholesteatoma were more numerous than the vessels in the adjacent normal skin of the auditory meatus; VEGF-positive blood vessels in the granulation tissue cholesteatoma are more numerous that the vessels in the adjacent normal skin of the auditory meatus.

Conclusion: The observed increased angiogenesis in granulation tissue of cholesteatoma might be triggered by the increased expression of VEGF which is secreted by many structures and cells in perimatrix of cholesteatoma.

The studies characteristics of the active angiogenesis were markedly enhanced in the biopsies from congenital cholesteatoma form. The results suggest the important role of angiogenesis in the growth of cholesteatoma and in aggressiveness of congenital pediatric type

Key words: Cholesteatoma, Adults, Children, Angiogenesis, VEGF, CD-31