gms | German Medical Science

80. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e. V.

Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e. V.

20.05. - 24.05.2009, Rostock

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Dysbalance of expression of cyclooxygenases – a possible key role in the pathogenesis of nasal polyposis

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  • corresponding author Kai Fruth - Hals-, Nasen-, Ohrenklinik und Poliklinik Mainz, Mainz, Germany
  • Chengjing Zhu - Hals-, Nasen-, Ohrenklinik und Poliklinik Mainz, Mainz, Germany
  • Juergen Brieger - Hals-, Nasen-, Ohrenklinik und Poliklinik Mainz, Mainz, Germany
  • Wolf Mann - Hals-, Nasen-, Ohrenklinik und Poliklinik Mainz, Mainz, Germany

German Society of Oto-Rhino-Laryngology, Head and Neck Surgery. 80th Annual Meeting of the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery. Rostock, 20.-24.05.2009. Düsseldorf: German Medical Science GMS Publishing House; 2009. Doc09hno099

doi: 10.3205/09hno099, urn:nbn:de:0183-09hno0994

Veröffentlicht: 22. Juli 2009

© 2009 Fruth et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielfältigt, verbreitet und öffentlich zugänglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.

Gliederung

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Introduction: It is to assume that cyclooxygenases play a decisive role in the pathogenesis of nasal polyposis.

Cyclooxygenases 1 (Cox-1) and 2 (Cox-2) are relevant in arachidonic acid metabolism and are therefore essential for the synthesis of prostaglandins.

However, it s still unknown in which extent a different expression of the cyclooxygenases has an impact on the responsible pathomachanism of polyposis nasi.

Methods: 87 tissue surgical specimens were immunohistochemically labeled for Cox-1 and Cox-2. These specimens were taken from patients with nasal obstruction without inflammatory disease during turbinate surgery and from patients suffering from chronic rhinosinusitis with polyposis. Staining intensities were semiquantitatively estimated and statistically analyzed.

Results: In nasal polyps the expression of Cox-1 was significantly higher than in specimens without inflammatory disease. On the other hand Cox 2 expression was labelled similarly in nasal polyps and in specimens without inflammatory disease.

Conclusion: These data show a dysbalance of Cox expression in nasal polyps. This dysbalance might play a key role in the pathogenesis of nasal polyposis.