gms | German Medical Science

80. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e. V.

Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e. V.

20.05. - 24.05.2009, Rostock

Loss of basal cell keratin 14 reflects increased risk of recurrence in surgically resected sinonasal inverted papilloma

Meeting Abstract

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  • corresponding author Sven Gunia - Department of Pathology, HELIOS Klinikum Bad Saarow, Bad Saarow, Germany
  • author Dieter Liebe - Department of Otorhinolaryngology, HELIOS Klinikum Bad Saarow, Bad Saarow, Germany
  • author Stefan Koch - Department of Pathology, HELIOS Klinikum Bad Saarow, Bad Saarow, Germany

German Society of Oto-Rhino-Laryngology, Head and Neck Surgery. 80th Annual Meeting of the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery. Rostock, 20.-24.05.2009. Düsseldorf: German Medical Science GMS Publishing House; 2009. Doc09hno087

DOI: 10.3205/09hno087, URN: urn:nbn:de:0183-09hno0876

Veröffentlicht: 22. Juli 2009

© 2009 Gunia et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielfältigt, verbreitet und öffentlich zugänglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

Aims: To evaluate selected markers in terms of their possible relation to the development of recurrence in microsurgically resected sinonasal inverted papilloma (SIP) in order to advance our understanding of the mechanisms pathogenetically involved, and to identify novel biomarkers for individual risk assessment in SIP.

Methods: Retrospective computerized database analysis and thorough review of medical charts was performed in order to identify all patients with newly diagnosed SIP who underwent microinvasive endonasal surgery at the HELIOS Klinikum Bad Saarow (the former HUMAINE Klinikum Bad Saarow) and at the Klinikum Hoyerswerda gGmbH (Germany) between 1985 and 2005, yielding a total of 73 patients with newly diagnosed SIP. Amongst these, 22 patients (30.1%) developed recurrence during follow-up which were also microsurgically resected. Therefore, archival paraffin-wax-embedded tissues comprising a total of 95 SIP were immunostained for a panel of selected antigens (Ki67/CK5/CK14/E-cadherin/CD56) functionally involved in cellular adhesion structures or (indirectly) in proliferative activity.1-3 Adjacent non-papillomatous sinonasal mucosa was available in all cases and served as normal controls.

Results: Increased proliferative activity (Ki67) and loss of basal cell keratin 14 (CK14) expression were found to be related to the development of recurrence in microsurgically resected SIP.

Conclusion: Our findings might advance our understanding of the pathogenesis behind the development of recurrence in microsurgically resected SIP by focusing on so far neglected alterations of cell-matrix connections at the epithelial-stromal interface in SIP, and might hint at CK14 as to represent a possible novel biomarker for individual risk assessment in microsurgically resected SIP. This notion remains to be confirmed by larger advanced prospective clinical studies.


References

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Hatakeyama S, Hayashi S, Yoshida Y, et al. Retinoic acid disintegrated desmosomes and hemidesmosomes in stratified oral keratinocytes. J Oral Pathol Med. 2004;33:622-8.
2.
Dejmek JS, Dejmek A. The reactivity to CK5/6 antibody in tumor cells from non-small cell lung cancers shed into pleural effusions predicts survival. Oncol Rep. 2006;15:583-7.
3.
Grobholz R, Griebe M, Sauer CG, et al. Influence of neuroendocrine tumor cells on proliferation in prostatic carcinoma. Hum Pathol. 2005;36:562-70.