Artikel
Malignant tumors of the nose and paranasal sinuses – diagnosis and therapeutic options
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Veröffentlicht: | 8. Juli 2008 |
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Gliederung
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Introduction: Despite their rareness, expanding lesions of the nose and paranasal sinuses can represent tumors of multiple entities. Due to non-specific symptoms, diagnosis often takes place at advanced stages and thus significantly affects therapy and prognosis.
Materials and methods: Retrospective analysis of data concerning diagnosis and therapy of 28 patients with malignancies of the nose and paranasal sinuses treated between 2002 and 2007 in Zentralklinikum Augsburg. This collective has been evaluated regarding the entity of the tumor, approach to therapy and five year overall survival rate.
Results: Among the entities described there were aesthesioneuroblastoma, adenocarcinoma, adenoid cystic carcinoma, squamous cell carcinoma and metastases of other primaries. The five year rate of survival is closely related to local control. Depending on the entity it varied from 25 to 60%. Individual therapy included primary surgery of the tumor and combined radiochemotherapy where appropriate.
Discussion: The choice both of surgical methods and radiotherapy is limited by the anatomical proximity to vital structures. Early diagnosis via imaging techniques and biopsies are crucial in achieving good long term follow up results. Safe surgical resection combined with radiochemotherapy (if required) and closely monitored follow-ups are essential.