gms | German Medical Science

77. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e. V.

Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e. V.

24.05. - 28.05.2006, Mannheim

Long term results of the leukotriene antagonist Montelukast in controlling sinunasal polyposis in aspirin triad disease

Kontrolle der Polyposis nasi mit dem Leukotrienrezeptorantagonisten Montelukast bei Patienten mit Analgetikaintoleranz – gehäufte Therapieversager bei Langzeittherapie

Meeting Abstract

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  • corresponding author presenting/speaker Stefan Tesche - Medical School Hamburg. Department of Oto,-Rhino,-Laryngology/ Head and Neck-Surgery, Hamburg, Germany
  • Adrian Münscher - Medical School Hamburg. Department of Oto,-Rhino,-Laryngology/ Head and Neck-Surgery, Hamburg, Germany
  • Thomas Grundmann - Department of Oto,-Rhino,-Laryngology/ Head and Neck-Surgery - Asklepios Hospital Altona, Hamburg, Germany

German Society of Otorhinolaryngology, Head and Neck Surgery. 77th Annual Meeting of the German Society of Otorhinolaryngology, Head and Neck Surgery. Mannheim, 24.-28.05.2006. Düsseldorf, Köln: German Medical Science; 2006. Doc06hno088

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter: http://www.egms.de/de/meetings/hno2006/06hno088.shtml

Veröffentlicht: 7. September 2006

© 2006 Tesche et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielf&aauml;ltigt, verbreitet und &oauml;ffentlich zug&aauml;nglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

Introduction: Recurrence of nasal polyps after sinus surgery is a common problem in patients with aspirin triad disease (ATD). Overproduction of leukotrienes accounts for the abnormalities in these patients.

Patients and Methods: We present the long term results of 13 patients with ATD, which were treated with Montelukast 10 mg daily after sinus surgery. The duration of follow up ranged from 9 to 84 months (mean: 39). Outcome measures included symptom scores and endoscopic findings.

Results: After follow up duration of 19 months (mean) we found a good local control of sinus symptoms and nasal polyposis in 10 of 13 patients. Only three showed relevant recurrence of polyps (23%). This number of patients increased during further follow up to 61 % within 9 to 84 months (mean: 31). No side effects of Montelukast occurred.

Conclusion: Long term medication of Montelukast showed a remarkable decrease of efficacy in controlling sinunasal polyposis in aspirin triad disease over time. The reasons are unclear.

Review of the latest literature showed a good disease control after desensitization therapy with only low maintenance doses of aspirin and therefore no or only few side effects. By date we recommend Montelukast as standby in cases of unsuccessful desensitization or contraindications and not as first therapy of choice.