gms | German Medical Science

77. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e. V.

Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e. V.

24.05. - 28.05.2006, Mannheim

Epidemiological and clinical characteristics of the nasopharyngeal cancer in association to the EBV immunological status

Meeting Abstract

  • corresponding author Theodoros Papadas - ENT Department, University Hospital of Patras, Patras, Griechenland
  • author Eleni Jelastopulu - Medical School, University of Patras, Patras, Griechenland
  • Konstantinos Kourelis - University Hospital of Patras, Patras, Griechenland
  • Panos Goumas - University Hospital of Patras, Patras, Griechenland

German Society of Otorhinolaryngology, Head and Neck Surgery. 77th Annual Meeting of the German Society of Otorhinolaryngology, Head and Neck Surgery. Mannheim, 24.-28.05.2006. Düsseldorf, Köln: German Medical Science; 2006. Doc06hno072

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter: http://www.egms.de/de/meetings/hno2006/06hno072.shtml

Veröffentlicht: 7. September 2006

© 2006 Papadas et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielf&aauml;ltigt, verbreitet und &oauml;ffentlich zug&aauml;nglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

Introduction: Exposition to the Epstein Barr virus (EBV) has been associated to the nasopharyngeal cancer (NPC). This study examines the possible involvement of a latent EBV infection in the development of NPC, as well as the possibility of the diagnostic assurance and control of therapy success.

Methods: The study included 37 patients, who were diagnosed and histologically confirmed with the presence of NPC in the period of 1990 to 2005 in the ENT Department of the University Hospital of Patras, as well as 11 control persons, three of them with otherwise located cancers. A standardized questionnaire was administered to both, patients and controls, in order to collect demographic and clinical data as well as information about risk factors (smoking, alcohol consumption, occupational exposure). In 11 patients with NPC and in all controls titre levels of different EBV antibodies (against early antigen (EA) and virus capsid antigen (VCA)) in serum were quantified. Statistical analyses were performed using SPSS v.12.0.

Results: In 84% of the patients smoking in association with occupational exposure was recognised as a substantial risk factor. The 3-year-survival-rate was 42%. Statistically significant differences regarding the titre levels of the IgG anti-VCA as well as IgG anti-EA were observed in the group of the NPC patients compared to the control group, while no IgM antibodies against VCA could be determined, neither in the NPC nor in the control group.

Conclusion: Occupational exposure, smoking as well as infection with EBV are to be recognised as important risk factors in the development of NPC. Thus it appears that a stricter observation of these risk groups is advisable, including EBV serology, in order to detect NPC in an early stage and to initiate an appropriate and effective therapy.