gms | German Medical Science

77. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e. V.

Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e. V.

24.05. - 28.05.2006, Mannheim

The expression of classic cadherins in cochlea during chicken embryonic development

Meeting Abstract

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  • corresponding author Hong Wang - Hospital of Otorhinolaryngology, Friedrich Schiller University Jena, Jena, Germany
  • Christoph Redies - Institute of Anatomy I, Friedrich Schiller University Jena, Jena, Germany
  • Hilmar Gudziol - Hospital of Otorhinolaryngology, Friedrich Schiller University Jena, Jena, Germany
  • Jiankai Luo - Institute of Anatomy I, Friedrich Schiller University Jena, Jena, Germany

German Society of Otorhinolaryngology, Head and Neck Surgery. 77th Annual Meeting of the German Society of Otorhinolaryngology, Head and Neck Surgery. Mannheim, 24.-28.05.2006. Düsseldorf, Köln: German Medical Science; 2006. Doc06hno036

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter: http://www.egms.de/de/meetings/hno2006/06hno036.shtml

Veröffentlicht: 7. September 2006

© 2006 Wang et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielf&aauml;ltigt, verbreitet und &oauml;ffentlich zug&aauml;nglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

The cochlea is a complex sensory organ responsible for sound detection. The interaction of the specialized sensory hair cells with the tectorial membrane is responsible for the onset and tuning of hearing in the Corti organ of the inner ear. In this study, by immunohistochemistry we showed that some classic cadherins were specifically expressed in the different parts of cochlea at embryonic incubation day 11 to 20 during chicken inner ear development. N-cadherin was exclusively expressed in the supporting cells and the tectorial membrane, whereas R-cadherin was expressed in the homogene cells and the tectorial membrane. Furthermore, E-cadherin was present in the entire basilar papilla, in the homogene cells and the tegmentum vasculosum, whereas cadherin-6B was located in the hair cells, and the tegmentum vasculosum. At last, cadherin-7 was expressed in the cochlear ganglion and its neurites. The presence of cadherins in the cochlea during chicken development suggested that cadherins play a role in the normal development of the auditory system, for example, in the formation of the tectorial membrane, the anchorage of the tectorial membrane to the supporting cells, and the guidance of neurites in the cochlear nerve.