gms | German Medical Science

77. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e. V.

Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e. V.

24.05. - 28.05.2006, Mannheim

Surgical therapy of nasal polyposis does not influence the postoperative production of cytokines

Die chirurgische Therapie der Polyposis nasi hat keinen Einfluss auf die postoperative Zytokinproduktion

Meeting Abstract

Suche in Medline nach

  • corresponding author presenting/speaker Martin Wagenmann - HNO-Klinik, Universitätsklinikum Düsseldorf, Düsseldorf, Germany
  • author Naglaa Mansour - HNO-Klinik, Universitätsklinikum Düsseldorf, Düsseldorf, Germany
  • author Adam Chaker - HNO-Klinik, Universitätsklinikum Düsseldorf, Düsseldorf, Germany

German Society of Otorhinolaryngology, Head and Neck Surgery. 77th Annual Meeting of the German Society of Otorhinolaryngology, Head and Neck Surgery. Mannheim, 24.-28.05.2006. Düsseldorf, Köln: German Medical Science; 2006. Doc06hno029

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter: http://www.egms.de/de/meetings/hno2006/06hno029.shtml

Veröffentlicht: 7. September 2006

© 2006 Wagenmann et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielf&aauml;ltigt, verbreitet und &oauml;ffentlich zug&aauml;nglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

The amount of cytokine production in nasal polyposis not only correlates with the preoperative situation and the inflammatory status, but also with the postoperative results. To further analyze this relation, we prospectively investigated the production of Th1- and Th2-cytokines in the nasal mucosa after endoscopic sinus surgery for 6 months in 25 patients with bilateral nasal polyposis. To this end, we performed nasal scrapings in the middle nasal meatus preoperatively, 1, 2, 3, and 6 months postoperatively. The production of the cytokines IL-4 and IFN-γ in the collected cells were measured using ELISPOT-assays. At the same time clinical data (symptomscores and polyp scores (Lildholdt 1997)) were documented. For statistical analyses, non-parametric tests (One-way ANOVA with Bonferroni-correction) were employed. Symptomscores and polyp scores were significantly improved (p<0.001) from the first to the sixth month after surgery. The production of the cytokines IL-4 and IFN-γ was detectable at all timepoints and in all specimen. In contrast to the clinical parameters, there were no significant changes (p>0.5) in the number of cytokine-producing cells in the mucosa at any timepoints. These results emphasize the relevance of the chronic inflammatory nature of nasal polyposis since the increased production of cytokines persists despite improvements of symptoms and endoscopic findings. This points to the paramount importance of anti-inflammatory treatment even after clinically successful surgery of nasal polyposis.