gms | German Medical Science

77. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e. V.

Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e. V.

24.05. - 28.05.2006, Mannheim

Application of Auditory Brainstem and Cognitive Responses in Differential Diagnosis of Central Nervous System Diseases

Meeting Abstract

German Society of Otorhinolaryngology, Head and Neck Surgery. 77th Annual Meeting of the German Society of Otorhinolaryngology, Head and Neck Surgery. Mannheim, 24.-28.05.2006. DŘsseldorf, K÷ln: German Medical Science; 2006. Doc06hno011

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Veröffentlicht: 7. September 2006

© 2006 Tˇth et al.
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The frequency of the stimuli influence the features of evoked potentials. Usually about 10 Hz stimulus frequency is employed at BAEP examinations, because responses are most stable at this frequency. The greater the frequency of the stimuli the most valuable changes of the characteristics of the BAEP could be found. We performed a systematic series of measurements in order to specify how the values of latencies and amplitudes change at the stimulus rates above 10 Hz in case of healthy patients. And other hand what differences could be found between the healthy and the patients suffered from central nervous system diseases in the same measuring circumstances. The cognitive components of auiditory event-related potentials (ERP) signify the brain’s detection of acoustic change. Theese endogenous cortical responses (mismatch negativity, N2b and P300) reflects the neurophysiologic processes that underlie auditory discrimination.

We recorded auditory brainstem and cognitive responses to study the central auditory processes in 14 healthy persons (they have normal hearing) and 10 patients suffered from central nervous system disease (sclerosis multiplex). We performed BAEP investigations using 14 different frequency of stimuli (10-64 Hz) and cognitive ERP investigations using acoustic oddball paradigm under active condition: the stimuli consisted of 1000 Hz frequent and 2000 Hz deviant (20 % sequental probability) stimuli presented in pseudorandom order with a fixed interstimulus interval of 1 s.

We conclude that increasing the stimulus rate the latencies of each BAEP–peaks and interpeak latencies become longer and the amplitudes decreased. In case of patients suffered from central nervous system diseases these disturbances were more definite. The most definite changes could be seen in case of latencies of IV/V. waves. The normal BAEP examinations could be expanded with these forced increase of the frequency of stimuli. Our results shows that the problems of central nervous system influence the waveform of cognitive event-related potential components including MMN, N2b and P300. The amplitudes was decreased and the latencies was increased in patients’ group compared with control group. The difference was most definit in the case of P300 component. Finally we suggest that the BAEP examinations using different frequency of stimuli and cognitive ERP examinations could be a useful method in differential diagnosis of the central nervous system diseases.