gms | German Medical Science

76. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e. V.

Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e. V.

04.05. - 08.05.2005, Erfurt

Immunohistochemical profiles on a tissue-microarray of 59 malignant parotideal tumors and their impact for tumorigenesis

Meeting Abstract

  • corresponding author Jürgen Alberty - Klinik und Poliklinik für HNO-Heilkunde, UKM, Münster
  • Heike Tappe - Klinik und Poliklinik für HNO-Heilkunde, UKM, Münster
  • Jens Packeisen - Institute of Pathology, UKM, Münster
  • Horst Bürger - Institute of Pathology, UKM, Münster
  • Wolfgang Stoll - Klinik und Poliklinik für HNO-Heilkunde, UKM, Münster
  • Eberhard Korsching - Institute of Pathology, UKM, Münster
  • Christian August - Institute of Pathology, UKM, Münster

Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie. 76. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e.V.. Erfurt, 04.-08.05.2005. Düsseldorf, Köln: German Medical Science; 2005. Doc05hno666

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter: http://www.egms.de/de/meetings/hno2005/05hno145.shtml

Veröffentlicht: 22. September 2005

© 2005 Alberty et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielf&aauml;ltigt, verbreitet und &oauml;ffentlich zug&aauml;nglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

Salivary gland tumors are characterized by a wide spectrum of histological and immunohistochemical differentiation. Therefore they are especially suitable to study differences as well as possible common origins in stem cells. Immunohistochemical data of large tumor collective can be further analyzed by means of biomathematical analysis.

Methods: Classification of 59 malignant epithelial parotideal tumors. Immunohistochemical investigation by a tissue microarray-technique; semiquantitative scoring of immunohistochemical findings and correlation by biomathematical cluster analysis.

Results: In relation to tumor entities the immunohistochemical profiles were distributed on four divergent clusters. One cluster was characterized by a strong Cytokeratin 5/6 expression; in this cluster (assumed to represent a more stem-cell associated immunophenotype) only squamous cell carcinomas, mucoepidermoid carcinomas and myoepithelial carcinomas were present. Another cluster was inversely characterized by a strong Cytokeratin 8/18 expression, in this group only salivary duct carcinomas or NOS-adenocarcinomas were present. Two more clusters were characterized by more heterogeneous immunohistochemical profiles. Clusters with Cytokeratin 5/6 (and inversely 8/18) were significantly related to the grade of expression of certain proliferation associated antigens. Such findings may contribute to further classification of salivary gland tumors beyond the borders of classical histological tumor entities.

Conclusions: The results assume – parallel to findings in carcinomas of the female breast - common stem cells to play a role in the tumorigenesis of malignant epithelial tumors of the parotis.