gms | German Medical Science

76. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e. V.

Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e. V.

04.05. - 08.05.2005, Erfurt

Discoidin domain receptor 1 (DDR1) and its function in the inner ear

Meeting Abstract

  • corresponding author Angela-Maria Meyer zum Gottesberge - Dept. of Otorhinolaryngology, University of Düsseldorf
  • Bogdan Beirowski - Dept. of Nephrology, University of Köln
  • Thomas Massing - Dept. of Otorhinolaryngology, University of Düsseldorf
  • Ursula Becker-Lendzian - Dept. of Otorhinolaryngology, University of Düsseldorf
  • Manfred Weber - Dept. of Nephrology, University of Köln
  • Oliver Gross - Dept. of Nephrology, University of Köln

Deutsche Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie. 76. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie e.V.. Erfurt, 04.-08.05.2005. Düsseldorf, Köln: German Medical Science; 2005. Doc05hno701

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter: http://www.egms.de/de/meetings/hno2005/05hno066.shtml

Veröffentlicht: 22. September 2005

© 2005 Meyer zum Gottesberge et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielf&aauml;ltigt, verbreitet und &oauml;ffentlich zug&aauml;nglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

Changes in the basement membrane (BM) structure are important phenomena in the development of both common acquired and rare inherited diseases. A variety of pathologic entities exist in which the inner ear and kidney are simultaneously affected and alterations of the basement membrane (BM) in humans and animal occur. The compounds of the BM in glomeruli and of the inner ear are similar. DDR1 is a recently discovered member of the receptor tyrosine kinase subfamily, that is activated by its collagen, A deficit of DDR1 leads to alteration of the glomerular basement membrane in the kidney (Gross et al. 2004). Immunohistochemistry was applied to investigate (i) the distribution of the DDR1 receptors in the inner ear and (ii) electron microscopy in order to detect the ultrastrucural alterations caused by DDR1 deficiency in DDR1+/- mice. DDR1 immunostaining was detected mainly in the stria vascularis, in the supporting cells of the organ of Corti and less in the spiral ganglion and nerve. Otopathological changes of DDR-/+ mice inner ear were closely related to the location of the DDR1. The most progressive alterations were related to the stria vascularis, where accumulation of the electron dense compounds, presumably collagen, occurs. Our preliminary results stress that DDR1 play an important role in the stria vascularis and essential for the function of the the inner ear .