gms | German Medical Science

53. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie e. V. (GMDS)

Deutsche Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie

15. bis 18.09.2008, Stuttgart

Aggregation of colorectal adenoma with other malignancies in Swedish families

Meeting Abstract

  • Eva Hiripi - Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
  • Justo Lorenzo Bermejo - Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
  • Jan Sundquist - Karolinska Institute, Center for Family and Community Medicine, Huddinge, Sweden
  • Kari Hemminki - Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

Deutsche Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie. 53. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie (gmds). Stuttgart, 15.-19.09.2008. Düsseldorf: German Medical Science GMS Publishing House; 2008. DocP-2

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter: http://www.egms.de/de/meetings/gmds2008/08gmds027.shtml

Veröffentlicht: 10. September 2008

© 2008 Hiripi et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielf&aauml;ltigt, verbreitet und &oauml;ffentlich zug&aauml;nglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

Background & Aim

Most colorectal cancers develop from benign adenomatous polyps. Risks for colorectal adenoma for individuals with a family history of extracolorectal cancer have not been studied.

Materials and Methods

Familial relative risks (RRs) for colorectal adenoma were estimated based on the offspring generation of the Swedish Family-Cancer Database, which includes over 11.5 million individuals. RRs were calculated using Poisson regression.

Results

The risk of colorectal adenoma was increased among first degree relatives of patients with colorectal cancer (RR 2.71; 95% confidence interval (CI) 2.46-3.00). Family history of malignancies other than colorectal cancer was also associated with colorectal adenoma. We found an increased risk of colon adenoma for the offspring of individuals affected by stomach, lung, prostate and liver cancers and leukaemia; the relative risk for acute lymphoblastic leukaemia was 6.31 (95% CI 2.63-15.20). The risk of colon adenoma was increased among siblings of patients with endometrial and prostate cancers and with multiple myeloma. The offspring of patients with pancreatic and endometrial cancers and melanoma, and the siblings of patients with pancreatic, cervical, skin and nervous system cancers and multiple myeloma were at an increased risk of rectal adenoma.

Conclusions

Our results suggest that colorectal adenoma shares a genetic etiology with cancer even at extracolorectal sites. Some of the observed associations are probably related to known colorectal cancer syndromes. However, some cancer types that cluster in families affected by colorectal adenoma cannot be attributed to known cancer syndromes, such as lung, prostate and skin cancers, acute leukaemias and multiple myeloma.


References

1.
Hiripi E, Lorenzo Bermejo J, Sundquist J, Hemminki K. Association of colorectal adenoma with other malignancies in Swedish families. Br J Cancer. 2008;98(5):997-1000.