gms | German Medical Science

Kongress Medizin und Gesellschaft 2007

17. bis 21.09.2007, Augsburg

CARDIOVASCULAR RISK FACTORS AND ALL-CAUSE MORTALITY IN PATIENTS WITH CORONARY HEART DISEASE. RESULTS FROM THE EUROASPIRE COHORT STUDY IN THE REGION OF MUENSTER, GERMANY

Meeting Abstract

Suche in Medline nach

  • Christof Prugger - Universität Münster, Münster
  • Jürgen Wellmann - Universität Münster, Münster
  • Jan Heidrich - Universität Münster, Münster
  • Ulrich Keil - Universität Münster, Münster

Kongress Medizin und Gesellschaft 2007. Augsburg, 17.-21.09.2007. Düsseldorf: German Medical Science GMS Publishing House; 2007. Doc07gmds658

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter: http://www.egms.de/de/meetings/gmds2007/07gmds658.shtml

Veröffentlicht: 6. September 2007

© 2007 Prugger et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielfältigt, verbreitet und öffentlich zugänglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

Background: A priority in preventive cardiology is to reduce the risk of recurrent events in patients with established coronary heart disease to increase the chance of survival. EuroAspire is a cross-sectional study to evaluate the management of risk factors in patients with coronary heart disease. Aim of the present study was to follow up patients from EuroAspire I and II in the region of Muenster, Germany, and to determine the relationships between risk factor levels and all-cause mortality.

Methods: EuroAspire I was conducted between 1995 and 1996 and EuroAspire II between 1999 and 2000. Consecutive patients ≤ 70 years of age hospitalised for coronary artery bypass graft, percutaneous transluminal coronary angioplasty, acute myocardial infarction, or myocardial ischaemia were examined on average 19.5 months after the index event. Vital status of patients was registered up to 31 December 2005 and survival of patients was compared between surveys. Multivariate analysis was performed using Cox proportionate hazards models stratified by EuroAspire survey to estimate hazard rate ratios (HRR) for risk factors measured at the time of interview.

Results: A total of 382 (EuroAspire I) and 383 (EuroAspire II) patients were followed up over a mean period of 7.4 years. Proportion of patients surviving five years was 90.1% and 91.4%, respectively. Kaplan Maier survival curves of patients from EuroAspire I and II did not differ significantly (p=0.94). Diabetes [HRR 2.1; 95% CI: 1.4-3.2] and smoking [HRR 1.7; 95% CI: 1.0-2.9] were independent predictors for all-cause mortality. No statistical significant association was found between all-cause mortality and body mass index, hypertension, plasma lipids, or level of education.

Conclusion: Five year survival of patients with established coronary heart disease remained stable between EuroAspire I and II in the Muenster area. Smoking and diabetes represent key issues of secondary prevention in patients with established coronary heart disease.