gms | German Medical Science

Kongress Medizin und Gesellschaft 2007

17. bis 21.09.2007, Augsburg

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No association between serum insulin-like growth factor-1 and left ventricular hypertrophy

Meeting Abstract

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  • Nicole Aumann - Ernst-Moritz-Arndt Universität Greifswald, Institut für Epidemiologie und Sozialmedizin, Greifswald
  • Nele Friedrich - Ernst-Moritz-Arndt Universität Greifswald, Institut für Epidemiologie und Sozialmedizin, Greifswald
  • Marcus Dörr - Universität Greifswald, Klinik und Poliklinik für Innere Medizin B, Greifswald
  • Stephan B. Felix - Universität Greifswald, Klinik und Poliklinik für Innere Medizin B, Greifswald
  • Henri Wallaschofski - Universität Greifswald, Klinik und Poliklinik für Innere Medizin A, Greifswald
  • Henry Völzke - Ernst-Moritz-Arndt Universität Greifswald, Institut für Epidemiologie und Sozialmedizin, Greifswald

Kongress Medizin und Gesellschaft 2007. Augsburg, 17.-21.09.2007. Düsseldorf: German Medical Science GMS Publishing House; 2007. Doc07gmds471

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter: http://www.egms.de/de/meetings/gmds2007/07gmds471.shtml

Veröffentlicht: 6. September 2007

© 2007 Aumann et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielfältigt, verbreitet und öffentlich zugänglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.

Gliederung

Text

Background: Left ventricular hypertrophy (LVH) is a major cardiac sequel of hypertension and represents a powerful predictor of cardiovascular morbidity and mortality. Serum insulin-like growth factor-1 (IGF-1) mediates multiple physiological as well as pathophysiological responses in the cardiovascular system. Previous studies reported of a possible association between serum IGF-1 and LVH. The objectives of the present study were to investigate the association between serum IGF-1 levels and left ventricular mass (LVM) as well as LVH in a population-based study.

Methods: From the Study of Health in Pomerania a total number of 1,865 subjects were selected. Echocardiography was performed and LVM was calculated. LVH was defined as a LVM ≥294g for men and ≥198g for women. Serum IGF-1 concentration was determined by chemiluminescence immunoassays. Linear and logistic regressions were performed.

Results: LVH was present in 25.2% of the women and 12.1% of the men. In females and males, subjects with LVH were older, had a higher body mass index and waist-to-hip ratio. Hypertension and diabetes were more common in women and men with LVH. Women with LVH had significantly lower levels of serum IGF-1 compared to women without LVH. Multivariable analyses yielded no associations between serum IGF-1 levels and LVM as well as LVH neither in women nor in men.

Conclusions: In conclusion, in contrast to previous studies, our data showed no significant associations between serum IGF-1 levels and LVM as well as LVH.

Gliederung

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