gms | German Medical Science

Kongress Medizin und Gesellschaft 2007

17. bis 21.09.2007, Augsburg

DNA variants, plasma levels and variability of C-reactive protein in myocardial infarction survivors: results from the AIRGENE study

Meeting Abstract

  • Melanie Kolz - GSF - Forschungszentrum für Umwelt und Gesundheit, Neuherberg
  • Wolfgang Koenig - Medizinische Universitätsklinik, Ulm
  • Martina Müller - GSF - Forschungszentrum für Umwelt und Gesundheit, Neuherberg
  • Mariarita Andreani - Catholic University, Rome
  • Sonja Greven - GSF - Forschungszentrum für Umwelt und Gesundheit, Neuherberg
  • Thomas Illig - GSF - Forschungszentrum für Umwelt und Gesundheit, Neuherberg
  • Natalie Khuseyinova - Medizinische Universitätsklinik, Ulm
  • Demosthenes Panagiotakos - University of Athens Medical School, Athens
  • Göran Pershagen - Karolinska Institute, Stockholm
  • Veikko Salomaa - National Public Health Institute (KTL), Helsinki
  • Jordi Sunyer - Environmental Epidemiology Research Centre (CREAL), Barcelona
  • Annette Peters - GSF - Forschungszentrum für Umwelt und Gesundheit, Neuherberg

Kongress Medizin und Gesellschaft 2007. Augsburg, 17.-21.09.2007. Düsseldorf: German Medical Science GMS Publishing House; 2007. Doc07gmds205

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter: http://www.egms.de/de/meetings/gmds2007/07gmds205.shtml

Veröffentlicht: 6. September 2007

© 2007 Kolz et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielf&aauml;ltigt, verbreitet und &oauml;ffentlich zug&aauml;nglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

C-reactive protein (CRP) represents the classical acute-phase protein produced in the liver in response to inflammatory stimuli. The present study investigated the association of DNA variants within the CRP gene and genes more upstream in the inflammatory cascade with differences in CRP concentrations and assessed its intra-individual variability as a marker of individual response. 1,003 myocardial infarction (MI) survivors were recruited in six European cities and CRP concentrations were measured repeatedly during a 6 month period. We investigated 114 polymorphisms in thirteen genes, all involved in the innate inflammatory pathway. We found two polymorphisms within the CRP gene, rs1800947 and rs1205, of which the minor alleles were strongly associated with lower levels of CRP (p<1.0e-06). A haplotype, identified by those two polymorphisms, was associated with the lowest CRP concentrations (p<1.0e-06). Additionally, the minor allele of a rare variant (rs1800894) in the promoter region of the interleukin-10 (IL10) gene was significantly associated with greater individual variability of CRP concentrations (p<1.0e-03).

The present study investigated the association of polymorphisms with inter- and intra-individual variability of CRP levels. Two minor alleles of CRP variants where associated with lower CRP concentrations. Regarding intra-individual variability, we observed an association with the minor allele of a variant in the promoter of the anti-inflammatory cytokine IL10.