gms | German Medical Science

50. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie (gmds)
12. Jahrestagung der Deutschen Arbeitsgemeinschaft für Epidemiologie (dae)

Deutsche Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie
Deutsche Arbeitsgemeinschaft für Epidemiologie

12. bis 15.09.2005, Freiburg im Breisgau

Effects of exposure to molds and parental atopy on asthma-related symptoms: the ISAAC I and III cross-sectional surveys in Münster

Meeting Abstract

  • Thomas Behrens - Bremer Institut für Präventionsforschung und Sozialmedizin, Bremen
  • Wasim Maziak - Center for Tobacco Studies, Aleppo, Syria
  • Stephan K. Weiland - Abteilung für Epidemiologie, Universität Ulm, Ulm
  • Peter Rzehak - Abteilung für Epidemiologie, Universität Ulm, Ulm
  • Ulrich Keil - Institut für Epidemiologie und Sozialmedizin, Universität Münster, Münster

Deutsche Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie. Deutsche Arbeitsgemeinschaft für Epidemiologie. 50. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie (gmds), 12. Jahrestagung der Deutschen Arbeitsgemeinschaft für Epidemiologie. Freiburg im Breisgau, 12.-15.09.2005. Düsseldorf, Köln: German Medical Science; 2005. Doc05gmds319

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter: http://www.egms.de/de/meetings/gmds2005/05gmds005.shtml

Veröffentlicht: 8. September 2005

© 2005 Behrens et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielf&aauml;ltigt, verbreitet und &oauml;ffentlich zug&aauml;nglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

Background and objectives

It has been shown that children who live in damp homes have an increased risk for the presence of asthma-related respiratory symptoms. Also, a history of parental atopy is a known risk factor for the development of asthma and atopic disease. We analyzed the independent and joint effects of parental atopy and exposure to molds on asthma-related outcomes.

Methods

Two cross-sectional surveys (1994/95 and 1999/2000) were conducted, using data from the ISAAC Phase I and III surveys, collected in Münster, Germany (N=6,996, response proportion 81.8%). Outcomes of interest were the prevalence of wheeze during the last 12 months, severity of wheeze (sleep disturbance because of wheeze and wheeze after exercise during the last 12 months), and current asthma (defined as 12-month wheezing plus a lifetime diagnosis of asthma) in 6-7 year-old children. Exposure was assessed with a question regarding dampness or visible molds in the child’s bedroom at present and during the first year of life. Risk estimates were calculated as prevalence ratios (PR) with 95% confidence intervals (CI), adjusting for several potential confounders.

Results

Positive associations were observed for exposure to molds (e.g. PR=1,28; 95% CI 0,99-1,68 for wheeze during the last 12 months) and parental atopy (PR=1,86; 95% CI 1,61-2,14 for 12-month wheeze and PR=3,35; 95% CI 2,38-4,72 for current asthma). Comparing the PR in four exposure categories, an excess risk of asthma-related outcomes was observed when joint effects of mold exposure and a positive family history of atopy were assessed (e.g. for wheeze: PR=1,83; 95% CI 1,58-2,11 in children with parental atopy, but without mold exposure; PR=1,12; 95% CI 0,73-1,71 in mold-exposed children without a history of parental atopy; and PR=2,60; 95% CI 1,58-4,34 in children with both factors).

Conclusions

In the ISAAC study a positive family history of atopy was a strong predictor for the development of asthma-related symptoms in children 6-7 years of age. Also, exposure to molds in the bedroom was a risk factors for the presence of respiratory symptoms suggestive of asthma. Parental atopy and exposure to molds did not have independent effects on the outcomes under observation.