gms | German Medical Science

G-I-N Conference 2012

Guidelines International Network

22.08 - 25.08.2012, Berlin

Barriers to implementation: research reporting bias and biased research agenda setting

Meeting Abstract

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  • I. Chalmers - James Lind Initiative, Oxford, UK

Guidelines International Network. G-I-N Conference 2012. Berlin, 22.-25.08.2012. Düsseldorf: German Medical Science GMS Publishing House; 2012. DocPL11

doi: 10.3205/12gin012, urn:nbn:de:0183-12gin0124

Veröffentlicht: 10. Juli 2012

© 2012 Chalmers.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen ( Er darf vervielf&aauml;ltigt, verbreitet und &oauml;ffentlich zug&aauml;nglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.



Most producers of clinical guidelines have recognised the importance, when developing guidelines, of reviewing systematically what can be known from existing research evidence. In addition, some guideline producers have contributed to the identification of important evidence gaps and the promotion of research to fill them. Guideline producers are thus in an influential position to ensure that, first and foremost, clinical research evidence serves the interests of patients and the public. I will present for discussion two of the many ways in which guideline producers can hold the clinical research community to account, and increase the likelihood that guidelines will impact positively of the health of patients and the public. First, biased under-reporting of clinical research compromises the validity of the work of clinical guideline producers. As a result of clinical trial registration we now know that the scale of this reporting bias is massive, and that it continues to result in substantial preventable suffering and death. Guideline producers must join the calls for an end to this unethical, unscientific and uneconomical practice. Second, there are mismatches between the questions and outcomes studied by researchers, which tend to reflect commercial and academic interests, and the questions and outcomes deemed important by patients, carers and clinicians. If research evidence is to inform decisions in clinical and public health practice, these mismatches will need to be identified and addressed, and clinical guideline producers are in a strong position to demand the changes that are needed.