gms | German Medical Science

15. Jahrestagung der Gesellschaft für Arzneimittelanwendungsforschung und Arzneimittelepidemiologie

Gesellschaft für Arzneimittelforschung und Arzneimittelepidemiologie

20.11. - 21.11.2008, Bonn

Cost analysis of internal medicine hospitalizations induced by adverse drug reactions in German hospitals

Ökonomische Aspekte von klinisch relevanten unerwünschten Arzneimittelwirkungen in der Inneren Medizin

Meeting Abstract

  • corresponding author D. Rottenkolber - Munich Center of Health Sciences, Ludwig-Maximilians-Universität, Munich, Germany
  • M. Rottenkolber - IBE - Department of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany
  • S. Schmiedl - Institute of Clinical Pharmacology, University of Witten/Herdecke, HELIOS Klinikum Wuppertal, Wuppertal, Germany
  • J. Szymanski - Institute of Clinical Pharmacology, University of Witten/Herdecke, HELIOS Klinikum Wuppertal, Wuppertal, Germany
  • J. Hasford - IBE - Department of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany
  • Netzwerk regionaler Pharmakovigilanzzentren

Gesellschaft für Arzneimittelanwendungsforschung und Arzneimittelepidemiologie e.V. (GAA). 15. Jahrestagung der Gesellschaft für Arzneimittelanwendungsforschung und Arzneimittelepidemiologie. Bonn, 20.-21.11.2008. Düsseldorf: German Medical Science GMS Publishing House; 2008. Doc08gaa27

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter: http://www.egms.de/de/meetings/gaa2008/08gaa27.shtml

Veröffentlicht: 6. November 2008

© 2008 Rottenkolber et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielf&aauml;ltigt, verbreitet und &oauml;ffentlich zug&aauml;nglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

Background and aim: German hospital reimbursement changed significantly as a result of the introduction of the Diagnosis Related Groups (DRG) in the year 2004. Based on this development no current data on the direct costs of adverse drug reactions (ADR) leading to hospital admissions in departments of internal medicine is available. The objective of our project is to quantify the ADR-related economic burden of the respective ADRs in Germany.

Material and method: 1,242 patient records of ADRs leading to internal medicine hospitalization were surveyed in 4 regional pharmacovigilance centres in Germany within the years 2006 and 2007. The WHO-Adverse Reaction Terminology record entries were re-coded in International Classification of Diseases (ICD-10-GM Version 2008) format and afterwards assigned to the matching DRG (G-DRG 2008) including supplementary and additional fees.

Results: Incidence of internal medicine hospitalization was estimated to approximately 3.25%. Mean age of patients was 71.3 years (SD 14.5). Average inpatient length of stay in the group was 9.3 days (SD 7.0) and therefore 2.3 days higher than average length of stay in German internal wards (7.0 days in the year 2006). Most frequent ADRs are gastrointestinal bleeding (n=205), hypoglycemia (n=201), and bradycardia (n=61). Average treatment costs of a single ADR were estimated to be approximately € 2,044 based on a state-wide base-rate of € 2,800.

Conclusion: Before the introduction of the DRG system, direct medical costs of ADR-treatment in Germany were € 400 million in the year 2002 [1]. This equals – given an ADR-incidence of 2.1% - case-related costs of € 3,700 per person. Our results provide an informative basis, that this former person-related amount seems to be too high against the background of DRG introduction. Considering the apparently higher incidence rate of 3.25%, the present total costs are approximately the same.

Data Collection was supported by BfArM: Fo. V-5329/68605/2008-2010


References

1.
Schneeweiss S, Hasford J, Göttler M, Hoffmann A, Riethling AK, Avorn J. Admissions caused by adverse drug events to internal medicine and emergency departments in hospitals: a longitudinal population-based study. Eur J Clin Pharmacol. 2002;58(4):285-91.