gms | German Medical Science

15. Jahrestagung der Gesellschaft für Arzneimittelanwendungsforschung und Arzneimittelepidemiologie

Gesellschaft für Arzneimittelforschung und Arzneimittelepidemiologie

20.11. - 21.11.2008, Bonn

Sex-differences in the rate of adverse drug reactions associated with diuretics

Geschlechtsspezifische Unterschiede bei unerwünschten Arzneimittelwirkungen im Zusammenhang mit Diuretika

Meeting Abstract

  • corresponding author Petra Thürmann - HELIOS Klinikum Wuppertal, Philipp Klee-Institute of Clinical Pharmacology, Wuppertal
  • Katrin Janhsen - Centre for Social Policy Research, University Bremen
  • Ulrike Werner - HELIOS Klinikum Wuppertal, Philipp Klee-Institute of Clinical Pharmacology, Wuppertal
  • Jacek Szymanski - HELIOS Klinikum Wuppertal, Philipp Klee-Institute of Clinical Pharmacology, Wuppertal
  • Silke Müller - Institute of Clinical Pharmacology, University Rostock
  • Bernd Drewelow - Institute of Clinical Pharmacology, University Rostock
  • Katrin Farker - Institute of Clinical Pharmacology, University Jena
  • Marion Hippius - Institute of Clinical Pharmacology, University Jena
  • Werner Siegmund - Institute of Clinical Pharmacology, University Greifswald
  • Karen May - Institute of Clinical Pharmacology, University Greifswald
  • Gerd Glaeske - Centre for Social Policy Research, University Bremen
  • Marietta Rottenkolber - Institute for Medical Informatics, Biometry and Epidemiology, University Munich
  • Joerg Hasford - Institute for Medical Informatics, Biometry and Epidemiology, University Munich

Gesellschaft für Arzneimittelanwendungsforschung und Arzneimittelepidemiologie e.V. (GAA). 15. Jahrestagung der Gesellschaft für Arzneimittelanwendungsforschung und Arzneimittelepidemiologie. Bonn, 20.-21.11.2008. Düsseldorf: German Medical Science GMS Publishing House; 2008. Doc08gaa11

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter: http://www.egms.de/de/meetings/gaa2008/08gaa11.shtml

Veröffentlicht: 6. November 2008

© 2008 Thürmann et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielf&aauml;ltigt, verbreitet und &oauml;ffentlich zug&aauml;nglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

Background and aim: From the database of the German Network of Regional Pharmacovigilance Centres (NRPZ) we have recently described that women experience more frequently ADRs associated with diuretics (Thürmann et al, Forum 2007), which could – in part – be explained by differences in prescribing. We therefore analysed sex-differences in diuretic prescribing.

Material and method: The database of the NRPZ consists of data from all patients admitted for ADRs in all internal medicine and emergency departments in the urban regions of Jena, Weimar, Greifswald, and Rostock, Germany. We analysed all ‘likely’ and ‘very likely’ ADRs caused by diuretics (ATC codes C03A-D plus combinations) between 2000 and 2006. Person-specific but non-identifying prescription data from a nationwide acting statutory health insurance company (GEK, about 1.6 Mio enrollees, 46% females) were analysed for the years 2000-2006 for the German federal states of Thuringia and Mecklenburg-Western Pomerania regarding age and sex specific prescription prevalences of diuretics. Sex-specific prescribing ratios were calculated and adjusted for the population in these regions.

Results: Diuretics caused serious ADRs in 375 patients, of which n = 258 occurred in women (68.8 vs 31.2 %, p <0.001). About 7% (MP) to 8% (TH) of the GEK enrollees received at least one diuretic prescription between 2000 and 2006. Among all age groups and all diuretic substance classes women were less likely to receive a diuretic prescription (MP: 6.7%; TH: 7.6%) than men (MP: 7.5%; TH: 8.5%). Sex-specific prescribing ratios (f:m) for enrollees aged 0 to 79 years varied between 0.8 (C03A/C03B, MP, 0-59y) and 1.3 (C03D, TH, 60-79y).

Conclusion: Available prescription data cannot explain the observed gender difference in the rate of ADRs with diuretics. However, a more detailed approach combining prescribing and ADR data and consideration of older age groups are required to substantiate our findings.

Supported by BfArM: Fo 2.1-68502-201

Prescription Data submitted by Gmuender ErsatzKasse (GEK)