Artikel
Breast cancer and exercise
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Autoren
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Ioannis Mitsakis
- 2nd Department of Obstetrics and Gynecology, Hippokratio General Hospital, Aristotle University, Thessaloniki, Greece
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Menelaos Mitsakis
- General Hospital-Health Center, Lemnos, Greece
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Charikleia Mitsaki
- Chirurgical Department, General Hospital, Serres, Greece
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Christos Lyrtzis
- Department of Orthopaedics, General Hospital, Kilkis, Greece
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Kyriaki Sianou
- Leadership and Management in Health Department, Kingston University, London, United Kingdom
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Aikaterini Anastasiou
- Department of Physiotherapy, Alexander Technological Educational Institute, Thessaloniki, Greece
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Aristotelis Loufopoulos
- 2nd Department of Obstetrics and Gynecology, Hippokratio General Hospital, Aristotle University, Thessaloniki, Greece
| Veröffentlicht: | 24. Oktober 2011 |
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Gliederung
Text
Objective: The aim of this study was to define the correlation between breast cancer and physical exercise and the mechanism for the prevention of breast cancer by physical exercise.
Material/Methods: The material emanates from a review of the international bibliography and from our own study in our Laboratory in Thessaloniki, Hellas.
Results: Sufficient evidence has accumulated to warrant an analysis of the relationship between exercise and breast cancer. Recent epidemiological studies confirm an inverse relationship between exercise and breast cancer, with stronger associations appearing for occupational activity than for leisure time or nonoccupational activity. Several plausible hypothesized biological mechanisms exist for the association between physical activity and breast cancer, including changes in endogenous sexual and metabolic hormone levels and growth factors, decreased obesity and central adiposity and possibly changes in immune function. Central adiposity has been particularly implicated in promoting metabolic conditions amenable to carcinogenesis. Exercising four or more hours a week may decrease hormone levels and help lower breast cancer risk.
Conclusion: The mechanisms are not well defined; several lines of evidence support the inclusion of low-to-moderate exercise as a preventive strategy for breast cancer.
References
- 1.
- Hsu HT, et al. Predictors of exercise frequency in breast cancer survivors in Taiwan. J Clin Nurs. 2011. DOI: 10.1111/j.1365-2702.2010.03690.x. [Epub ahead of print]
- 2.
- Loh SY. Physical activity and women with breast cancer: insights from expert patients. Asian Pac J Cancer Prev. 2011;12(1):87-94.
- 3.
- Lynch BM, et al. Associations of objectively assessed physical activity and sedentary time with biomarkers of breast cancer risk in postmenopausal women: findings from NHANES (2003-2006). Breast Cancer Res Treat. 2011. [Epub ahead of print]
- 4.
- Murphy EA, et al. Benefits of exercise training on breast cancer progression and inflammation in C3(1)SV40Tag mice. Cytokine. 2011 [Epub ahead of print].
- 5.
- Rahnama N, et al. The effects of exercise training on maximum aerobic capacity, resting heart rate, blood pressure and anthropometric variables of postmenopausal women with breast cancer. J Res Med Sci. 2010;15(2):78-83.
