gms | German Medical Science

104. Jahrestagung der Deutschen Ophthalmologischen Gesellschaft e. V. (DOG)

21. - 24.09.2006, Berlin

Needle revision with 5-fluorouracil application in the management of bleb failure after trabeculectomy

Meeting Abstract

Suche in Medline nach

  • S. Aliyeva - Department of Ophthalmology, Johannes Gutenberg-University, Mainz, Germany
  • N. Pfeiffer - Department of Ophthalmology, Johannes Gutenberg-University, Mainz, Germany

Deutsche Ophthalmologische Gesellschaft e.V.. 104. Jahrestagung der Deutschen Ophthalmologischen Gesellschaft (DOG). Berlin, 21.-24.09.2006. Düsseldorf, Köln: German Medical Science; 2006. Doc06dogSA.14.03

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter: http://www.egms.de/de/meetings/dog2006/06dog382.shtml

Veröffentlicht: 18. September 2006

© 2006 Aliyeva et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielf&aauml;ltigt, verbreitet und &oauml;ffentlich zug&aauml;nglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

Objective

The purpose of the study was to determine the efficacy of the postoperative needling revision with adjunctive 5-fluorouracil (5-FU) and to identify any complications of the procedure and risk factors associated with success or failure.

Methods

Thirty-eight eyes underwent one to five standard needling procedures at the different time following either trabeculectomy or phaco-trabeculectomy with or without adjunctive mitomycin C. The results of total 60 bleb needling procedures augmented with subconjunctival 5-fluorouracil injection were evaluated within the follow-up period ranging from 1 month to 10 years. Reduction in intraocular pressure (IOP) (>15 mmHg, ≤15 mmHg), number of glaucoma medications, complications and factors associated with outcome were analyzed.

Results

Mean preoperative intraocular pressure was 31.3 mmHg (range, 17 – 49 mmHg). In each eye it dropped immediately following surgery to 11.9 mmHg (≤15 mmHg in 45 cases). One month postoperatively mean IOP was 16.7 mmHg (range, 7 - 44 mmHg) being ≤15 mmHg in 23 cases. Three months following surgery mean IOP was 17.7 mmHg being ≤15 mmHg in 13 cases without hypotensive medications. Twenty-one eyes (55%) had the mean IOP=19.6 mm Hg at 6 months and twenty-two eyes (57.8%) had the mean IOP=19.3 mm Hg at 1 year follow-up. In 3 cases mean IOP was 17.7 mm Hg with no medications at 5 years after needling procedure. Postoperative injections of 5-fluorouracil were applied in 51 cases. The mean number of 5-FU injections was 7.8 (range, 0 – 36 injections). The average number of needling was 1.6, ranging from 0 to 5 procedures. There was a statistically significant reduction in mean number of topical antiglaucoma agents. No serious complications were encountered with the procedure.

Conclusions

These data suggest that needling of filtering bleb augmented with 5-FU is a safe and effective method in re-establishing drainage and lowering intraocular pressure.