gms | German Medical Science

104. Jahrestagung der Deutschen Ophthalmologischen Gesellschaft e. V. (DOG)

21. - 24.09.2006, Berlin

Cyanoacrylate versus fibrin glue in corneal perforations

Meeting Abstract

  • I. T. Shandurkov - Eye Department, University Hospital "St. Anna", Sofia, Bulgaria
  • P. V. Vassileva - Eye Department, University Hospital "St. Anna", Sofia, Bulgaria
  • A. D. Gantcheva - Eye Department, University Hospital "St. Anna", Sofia, Bulgaria
  • T. G. Hergeldzhieva - Eye Department, University Hospital "St. Anna", Sofia, Bulgaria

Deutsche Ophthalmologische Gesellschaft e.V.. 104. Jahrestagung der Deutschen Ophthalmologischen Gesellschaft (DOG). Berlin, 21.-24.09.2006. Düsseldorf, Köln: German Medical Science; 2006. Doc06dogDO.09.09

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter: http://www.egms.de/de/meetings/dog2006/06dog074.shtml

Veröffentlicht: 18. September 2006

© 2006 Shandurkov et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielfältigt, verbreitet und öffentlich zugänglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

Objective

To compare clinical results from application of cyanoacrylate versus fibrin glue for occlusion in cases with corneal perforations as a result of autoimmune disease or ocular herpes.

Methods

5 patients with corneal perforations up to 2 mm in diameter and positive Seidel’s sign were included in our study. One patient (corneal perforation associated with ankylosing spondilitis) was treated with autologous fibrin glue. In the other 4 patients (three with perforated herpetic ulcer and one with corneal ulcer associated with rheumatoid arthritis) we applied cyanoacrylate glue. Soft contact lens was placed on the cornea after glue consolidation.

Results

Excellent restoration of anterior chamber was achieved almost immediately after glue application. Severe hypotony was overcome and normal ocular pressure was measured on the first postoperative day. In spite of combined immunosuppressive therapy after glue application in the patient with ankylosing spondilitis the aggressive autoimmune melting of the cornea continued. All patients treated with cyanoacrylate glue kept corneal integrity even after removal of the glue two months later. During follow up period visual results were evaluated and underlying eye diseases treated as appropriate.

Conclusions

Application of autologous fibrin glue can provide temporary corneal occlusion, but it did not prevent further corneal melting in our patient with autoimmune disease - ankylosing spondilitis. Cyanoacrilate glue applied for small corneal lesions gives good long term results, because of its ability to adhere and hold fast for two or more months, during the self-healing processes restore ocular surface integrity.