gms | German Medical Science

102. Jahrestagung der DOG

Deutsche Ophthalmologische Gesellschaft e. V.

23. bis 26.09.2004, Berlin

Morphological changes of the retrobulbar optic nerve and its meningeal sheaths in glaucoma

Meeting Abstract

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  • corresponding author M. Pache - Augenklinik, Universitätsklinikum Freiburg; Universitäts-Augenklinik Basel, Schweiz
  • P. Meyer - Universitäts-Augenklinik Basel, Schweiz; Institut für Pathologie der Universitätsklinik Basel, Schweiz

Evidenzbasierte Medizin - Anspruch und Wirklichkeit. 102. Jahrestagung der Deutschen Ophthalmologischen Gesellschaft. Berlin, 23.-26.09.2004. Düsseldorf, Köln: German Medical Science; 2004. Doc04dogP 078

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter: http://www.egms.de/de/meetings/dog2004/04dog569.shtml

Veröffentlicht: 22. September 2004

© 2004 Pache et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielf&aauml;ltigt, verbreitet und &oauml;ffentlich zug&aauml;nglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

Objective

To focuss on possible remodelling of the retrobulbar portion of the optic nerve and its meningeal sheaths.

Methods

The bulbar segment of the orbital optic nerve portion from 25 donors with glaucoma (M:F=8:17; mean age 85±11 years) and 28 controls (M:F=14:14; mean age 79±8 years) were formalin-fixed, paraffin-embedded and sectioned in series. Sections were stained with PAS and Masson trichrome and histopathological examined by two blinded observers. The following parameters were evaluated: 1. Diameter of the optic nerve, 2. Thickness of the pia mater, 3. Distance between dura mater and pia mater, 4. Occurrence and amount of meningothelial cell nests in the subarachnoidal space, 5. Presence and number of corpora arenacea.

Results

The mean diameter of the optic nerve was decreased in glaucoma (2.9 vs 3.4 mm; p<0.003), whereas thickness of the pia mater was increased (0.1 vs. 0.08 mm, p<0.02). Distance between dura mater and pia mater tended to be enlarged in glaucoma, this finding, however, was not significant (0.37 vs. 0.29 mm, p=0.3). Occurrence and amount of meningothelial cell nests was increased in glaucoma (p<0.02). Presence and number of corpora arenacea did not differ between the groups.

Conclusions

As expected, the diameter of the optic nerve was reduced in glaucomatous eyes, and thickness of the pia mater was consecutively increased. Corpora arenacea are concretions composed of calcium and magnesium salts. The degree of calcification was thought to be associated to various diseases of the CNS. However, more recent studies suggest that the presence of corpora arenacea does not reflect a specific pathological state. We could find no association between glaucoma and number of corpora arenacea. Our most interesting finding was that occurrence and amount of meningothelial cell nests was increased in glaucoma. They present a focal compact cell proliferation comparable with a reactive process. In how far this reaction is pathogenetically related to glaucoma is not yet clear.