gms | German Medical Science

102. Jahrestagung der DOG

Deutsche Ophthalmologische Gesellschaft e. V.

23. bis 26.09.2004, Berlin

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Expression of human connective-tissue growth-factor (hCTGF) protein in membranes of posterior capsule opacification

Meeting Abstract

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  • corresponding author K. Wunderlich - Department of Ophthalmology, Department of Research, University of Basel, Basel/CH
  • J. Flammer - Department of Ophthalmology, University of Basel, Basel/CH
  • P. Meyer - Department of Ophthalmology, Department of Pathology, University of Basel, Basel/CH

Evidenzbasierte Medizin - Anspruch und Wirklichkeit. 102. Jahrestagung der Deutschen Ophthalmologischen Gesellschaft. Berlin, 23.-26.09.2004. Düsseldorf, Köln: German Medical Science; 2004. Doc04dogP 067

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter: http://www.egms.de/de/meetings/dog2004/04dog558.shtml

Veröffentlicht: 22. September 2004

© 2004 Wunderlich et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielfältigt, verbreitet und öffentlich zugänglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.

Gliederung

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Objective

Human connective tissue growth factor (hCTGF) appears to play a significant role in mediating fibrosis in several tissues. To gain further understanding of the role of hCTGF in the development of posterior capsule opacification (PCO) we investigated the location of hCTGF protein.

Methods

hCTGF protein was immunolocalized in paraffin-embedded sections of human eyes with PCO by using a specific antibody.

Results

In all samples, hCTGF protein could be detected in remnants of lens epithelial cells, which were located in the equatorial region of the capsular bag.

Conclusions

As shown in former studies, PCO membranes are composed of the wound healing markers collagen type I and tenascin. Here we can show that this expression is accompanied by the production of hCTGF protein in lens epithelial cells. These data support the hypothesis that hCTGF promotes PCO membrane formation by an autokrine mechanism in remnants of lens epithelial cells.