gms | German Medical Science

102. Jahrestagung der DOG

Deutsche Ophthalmologische Gesellschaft e. V.

23. bis 26.09.2004, Berlin

Qualitative assessment of the effect of photodynamic therapy in choroidal neovascularization secondary to pathologic myopia

Meeting Abstract

  • corresponding author U.E.K. Schnurrbusch - Klinik und Poliklinik für Augenheilkunde, Leipzig
  • C. Jochmann - Klinik und Poliklinik für Augenheilkunde, Leipzig
  • W. Einbock - Klinik und Poliklinik für Augenheilkunde, Leipzig
  • S. Wolf - Klinik und Poliklinik für Augenheilkunde, Leipzig

Evidenzbasierte Medizin - Anspruch und Wirklichkeit. 102. Jahrestagung der Deutschen Ophthalmologischen Gesellschaft. Berlin, 23.-26.09.2004. Düsseldorf, Köln: German Medical Science; 2004. Doc04dogFR.03.14

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter: http://www.egms.de/de/meetings/dog2004/04dog190.shtml

Veröffentlicht: 22. September 2004

© 2004 Schnurrbusch et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielf&aauml;ltigt, verbreitet und &oauml;ffentlich zug&aauml;nglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

Objective

To determine the long-term effect of photodynamic therapy (PDT) of choroidal neovascularization (CNV) secondary to pathologic myopia (PM).

Methods

We included patients with subfoveal CNV due to PM. They underwent PDT with verteporfin and were followed prospectively for a minimal follow-up of 24 months. Follow-up visits were scheduled every three months. To assess treatment effects we analyzed the number of letters in ETDRS-charts. A moderate loss or gain in visual acuity was defined by a change of more than 15 letters.

Results

83 patients (28 m, 52 f) aged from 18 to 83 years (58±14 years) with subfoveal CNV due to PM were included into the study. During the mean follow-up time of 32±6 months we performed 161 PDT treatments (mean: 1,9±0,9 treatments). At baseline initial visual acuity ranged from 30 - 73 letters (0.08 - 0.63) (mean 55±11 letters). After 12 month the visual acuity ranged from 19 - 80 letters (0.05 - 0.8) (mean 47±15 letters). After a period of 24 months follow-up the visual acuity ranged form 8 - 78 letters (0.03 - 0.8) (mean 47±17 letters). A moderate loss in visual acuity was observed in 15 patients (18%) after 12 months after the first PDT treatment session, and in 32 patients (38%) after 24 months follow up. Improvement of visual acuity was found in 16 patients (19%) after 12 months, and in 7 patients (8%) after 24 months. Out of 32 patients without reading ability, 10 patients (31%) ware able to read after 12 months. However, most of these (7 patients) had lost reading ability at 24 months again.

Conclusions

Most patients with CNV due to PM are young and are still working. For this reason the stabilization of visual acuity and reading ability is extremely important. Initially after PDT, a significant number of patients experienced an improvement of visual acuity and 20% of patient had improved visual acuity after 12 months. Most important, 30% of patients gained reading ability for a minimum of 12 months.