gms | German Medical Science

102. Jahrestagung der DOG

Deutsche Ophthalmologische Gesellschaft e. V.

23. bis 26.09.2004, Berlin

Following verteporfin-photodynamic therapy: cellular and humoral events in choroidal neovascular membranes

Meeting Abstract

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  • corresponding author S. Grisanti - Universitäts-Augenklinik Tübingen
  • O. Tatar - Universitäts-Augenklinik Tübingen
  • K. U. Bartz-Schmidt - Universitäts-Augenklinik Tübingen

Evidenzbasierte Medizin - Anspruch und Wirklichkeit. 102. Jahrestagung der Deutschen Ophthalmologischen Gesellschaft. Berlin, 23.-26.09.2004. Düsseldorf, Köln: German Medical Science; 2004. Doc04dogFR.03.07

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Veröffentlicht: 22. September 2004

© 2004 Grisanti et al.
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PDT leads to a selective damage of vascular endothelial cells through production of oxidative radicals within a confined localization and a precise time interval. These qualities predispose the method as an ideal treatment approach for choroidal membranes (CNVM) allowing the targeting of the neovascular component without interference with neural layers. However, the potential and success of the approach are considerably compromised: More than 90 % of cases recur 3 months after initial therapy. CNVM persistence and recurrence require frequent retreatments. Despite the obvious early angiographically visible effect, suggesting disappearance or occlusion of the neovascular complex, patients experience a mean visual loss of two ETDRS lines during the first 6 months after initiation of treatment. Obviously, the purely mechanistic approach is not sufficient to counteract the biological system and the multifactorial pathogenesis of choroidal neovascularization. Recurrence and vascular permeability changes are probably the consequence of biological reactions such as the release or inhibition of angiogenic factors. Herewith we present the combined results of a series of experiments and histological analysis of CNVM. The complex and time dependent cellular and humoral events may help to understand the clinical results of PDT and to modify the present therapeutical approach.