gms | German Medical Science

102. Jahrestagung der DOG

Deutsche Ophthalmologische Gesellschaft e. V.

23. bis 26.09.2004, Berlin

Concordance of binocular fundus autofluorescence in patients with age-related maculopathy

Meeting Abstract

  • corresponding author W. Einbock - Universitätsklinikum Leipzig, Klinik und Poliklinik für Augenheilkunde, Leipzig
  • A. Mößner - Universitätsklinikum Leipzig, Klinik und Poliklinik für Augenheilkunde, Leipzig
  • C. K. Brinkmann - Universitätsklinikum Leipzig, Klinik und Poliklinik für Augenheilkunde, Leipzig
  • U. E. K. Schnurrbusch - Universitätsklinikum Leipzig, Klinik und Poliklinik für Augenheilkunde, Leipzig
  • C. Jahn - Universitätsklinikum Leipzig, Klinik und Poliklinik für Augenheilkunde, Leipzig
  • F. G. Holz - Augenklinik, Universität Bonn, Bonn
  • S. Wolf - Universitätsklinikum Leipzig, Klinik und Poliklinik für Augenheilkunde, Leipzig

Evidenzbasierte Medizin - Anspruch und Wirklichkeit. 102. Jahrestagung der Deutschen Ophthalmologischen Gesellschaft. Berlin, 23.-26.09.2004. Düsseldorf, Köln: German Medical Science; 2004. Doc04dogFR.01.12

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter: http://www.egms.de/de/meetings/dog2004/04dog173.shtml

Veröffentlicht: 22. September 2004

© 2004 Einbock et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielf&aauml;ltigt, verbreitet und &oauml;ffentlich zug&aauml;nglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

Objective

Identification of the prognostic relevance of lipofuscin dependent fundus autofluorescence in patients with age-related maculopathy (ARM) is the aim of the "fundus autofluorescence in age-related macular degeneration" study group (FAM-Study). As member of this study group we analysed the correlation of AF patterns in patients with binocular soft drusen in ARM.

Methods

Patients with ARM were recruited from the outpatient department. Inclusion criteria were age > 50 years, the presence of binocular large soft drusen, visual acuity of 20/100 or better and no previous laser treatment of the eyes or appearance of other eye diseases. All patients underwent a detailed ophthalmological examination including ETDRS visual acuity, binocular funduscopy, and color fundus photography. AF imaging was performed with a confocal scanning laser ophthalmoscope (HRA, Heidelberg Engineering, Germany) following a standard protocol. The binocular AF images were analysed according to the new classification of the International Fundus Autofluorescence Classification Group (IFAG) and correlation of the AF patterns between fellow eyes was compared.

Results

Fifty one patients (35 woman, 16 men) aged from 55-80 years (mean 69±7 years) were examined. In 36 patients binocular AF images presented similar patterns. Reticular and speckled pattern showed 100% identical binocular occurrence. Patchy and focal patterns appeared also in high correlation binocularly (≥70%). Patients with varying patterns between both eyes presented combinations of all AF patterns except for reticular and speckled pattern. Patchy patterns were combined which every pattern type.

Conclusions

Imaging of fundus autofluorescence in patients with age-related maculopathy allows to identify different patterns of fundus AF. In 2/3 of the patients AF imaging showed similar binocular AF patterns. Reticular and speckled patterns seems to occur only binocularly.