gms | German Medical Science

102. Jahrestagung der DOG

Deutsche Ophthalmologische Gesellschaft e. V.

23. bis 26.09.2004, Berlin

Impact of stage of glaucomatous optic disc atrophy on parapapillary autofluorescence

Meeting Abstract

  • corresponding author A. Viestenz - Department of Ophthalmology, University Erlangen-Nürnberg, Erlangen
  • A. Langenbucher - Department of Ophthalmology, University Erlangen-Nürnberg, Erlangen
  • F. Horn - Department of Ophthalmology, University Erlangen-Nürnberg, Erlangen
  • T. Kaufmann - Department of Ophthalmology, University Erlangen-Nürnberg, Erlangen
  • C. Y. Mardin - Department of Ophthalmology, University Erlangen-Nürnberg, Erlangen

Evidenzbasierte Medizin - Anspruch und Wirklichkeit. 102. Jahrestagung der Deutschen Ophthalmologischen Gesellschaft. Berlin, 23.-26.09.2004. Düsseldorf, Köln: German Medical Science; 2004. Doc04dogDO.06.07

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter: http://www.egms.de/de/meetings/dog2004/04dog057.shtml

Veröffentlicht: 22. September 2004

© 2004 Viestenz et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielf&aauml;ltigt, verbreitet und &oauml;ffentlich zug&aauml;nglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

Objective

Impact of stage of glaucomatous optic disc atrophy on parapapillary autofluorescence (PAF).

Methods

A total of 271 eyes was examined in a controlled, prospective cross-sectional study (69 healthy control eyes, 57x ocular hypertension (OHT), 72x primary open angle glaucoma (POAG), 50x normal tension glaucoma (NTG), 23x pseudoexfoliation glaucoma (PSX). Eyes with any additional fundus pathologies were excluded. Two experienced ophthalmologists determined the stage of glaucomatous optic nerve atrophy according to Jonas using 15° fundus photography (Zeiss telecentric fundus camera). The parapapillary autofluorescence was visualized using a confocal scanning laser ophthalmoscope (HRA, Heidelberg Retina Angiograph) after excitation with argon laser (488 nm) in a spectrum above 500 nm.

Results

A significant increase of PAF area was found depending on the stage of glaucomatous optic disc atrophy (stage 0: 0.11±0.14 mm2, stage 1: 0.24±0.24 mm2, stage 2: 0.26±0.21 mm2, stage 3: 0.24 ±0.14 mm2, stage 4: 0.71±1.59 mm2). The PAF area became more distant from the optic nerve head in an ascending order of glaucoma stage (stage 0: 0.13±0.10 mm2, stage 1: 0.24±0.20 mm2, stage 2: 0.22±0.15 mm2, stage 3: 0.25 ±0.15 mm2, stage 4: 0.44±0.50 mm2). No difference of size of PAF area or PAF distance from the optic disc was observed between the glaucoma groups (POAG, NTG, PSX). There was no correlation found between PAF size/PAF distance and the duration of glaucomatous disease. Eyes with OHT showed a larger PAF area than healthy control eyes (p<0.001) and had a PAF area more adjacent to the optic disc in contrast to glaucoma eyes (p<0.02).

Conclusions

As a sign of pronounced lipofuscin accumulation in the parapapillary atrophic zone higher degrees of PAF can be detected in OHT and manifest glaucomas. The higher the degree of glaucoma stage was, the more did the PAF area increase and the more was the PAF distant from the optic nerve head. The analysis of PAF areas could be an important ophthalmologic tool for early diagnosis of OHT or glaucomas.