Artikel
The treatment of brain cancer with Drug-Nanoparticle complex
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Veröffentlicht: | 20. März 2006 |
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Gliederung
Text
The blood-brain barrier protects the brain against toxic substances that circulate in the bloodstream. It is formed by the endothelium of the brain vessels, the basal membrane and the neuroglial cells which makes it difficult to medicate patients with brain diseases such as Glioblastoma. However, we were able to bypass the blood-brain barrier with Polybutylcyano-acrylate-Nanoparticles (PBCA). These Nanoparticles have an average diameter size of about 100-300 nm and are very rapidly biodegraded. In our studies we found, that drugs like Doxorubicin loaded on Nanoparticles can increase the survive of rats suffering from brain cancer. The optimal amount of Doxorubicin Nanoparticle complexes lies between 4.5 and 7.5mg/kg relative to the weight of the rat.