gms | German Medical Science

27. Deutscher Krebskongress

Deutsche Krebsgesellschaft e. V.

22. - 26.03.2006, Berlin

Clinical relevance of selected biochemical parameter within amniotic fluid as markers of the disordered pregnancy and under special consideration of Zytokines and Tumormarkers

Meeting Abstract

  • corresponding author presenting/speaker Steffen Albrecht - Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, Universitätsklinikum Dresden, Deutschland
  • Susann Köhler - Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, Universitätsklinikum Dresden
  • Romy Büttner - Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, Universitätsklinikum Dresden
  • Thomas Zimmermann - Klinik und Poliklinik für VTG-Chirurgie, Universitätsklinikum Dresden
  • Gabriele Kamin - Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, Universitätsklinikum Dresden
  • Steffen Albrecht - Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, Universitätsklinikum Dresden
  • Wolfgang Distler - Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, Universitätsklinikum Dresden

27. Deutscher Krebskongress. Berlin, 22.-26.03.2006. Düsseldorf, Köln: German Medical Science; 2006. DocPO354

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter: http://www.egms.de/de/meetings/dkk2006/06dkk464.shtml

Veröffentlicht: 20. März 2006

© 2006 Albrecht et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielf&aauml;ltigt, verbreitet und &oauml;ffentlich zug&aauml;nglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

We tested 344 samples of amniotic fluid which were taken in 1996-2001. Determined through ELISA and RIA, one was able to find the interleukins IL6, IL8, IL15 and IL16, the adhesive molecules sICAM, VCAM, Apo1Fas and also the alpha-fetoprotein, the tumor necrosis factor II receptor, oxalic acid and the tumor marker CEA, CA15-3, CA125, CA19-9 and CA 72-4. For analyzing the results, 37 samples were put aside to have a comparison- group. On one hand the criterion for this group was an amniocentesis between the 15th and the 16th week of pregnancy and on the other hand no irregularities during the pregnancy, the delivery and the state of the baby after the delivery. All other pregnant women with noticeable differences formed separate groups with different diagnosis.

Most of the differences were found within the group of premature births. This group shows significant increase of IL8, sICAM, VCAM and CA 72-4.

VCAM was higher in the group with induced miscarriages because of the chromosomal harm.

Additionally, individual parameters were watched during the course of pregnancy. Using the correlation coefficient, an increase in sICaM, in TNF receptor, oxalic acid, as well as in the tumor markers CA 15-3, Ca 19-9 and in CA 72-4 was calculable along the progressing pregnancy.

Generally, oxalic acid (35,05µmol/l instead of 2,84µmol/l), CA 125 (5941,67 U/ml instead of <65U/ml) and CA 19-9 (1522 U/ml instead of <30 U/ml) were a lot higher in the samples of the amniotic fluid than the data of the serum of non-pregnant women.

Independent of the analysis, two cases, which showed steep inline in IL 8 and IL 6 (20 000pg/ml) in the amniotic fluid with starting amnionitis, were evaluated. The serum tallies were only 1/10 of the amniotic fluid tallies. Importantly, to nearly no extend could the c reaktive protein have been utilized in these cases.