gms | German Medical Science

27. Deutscher Krebskongress

Deutsche Krebsgesellschaft e. V.

22. - 26.03.2006, Berlin

TPF chemotherapy regimen in advanced head and neck cancer

Meeting Abstract

  • corresponding author presenting/speaker Mehran Baghi - Universitätsklinikum, Frankfurt am Main , Deutschland
  • Markus Hambek - Universitätsklinikum, Frankfurt am Main
  • Jens Wagenblast - Universitätsklinikum, Frankfurt am Main
  • Wolfgang Gstoettner - Universitätsklinikum, Frankfurt am Main
  • Rainald Knecht - Universitätsklinikum, Frankfurt am Main

27. Deutscher Krebskongress. Berlin, 22.-26.03.2006. Düsseldorf, Köln: German Medical Science; 2006. DocOP243

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Veröffentlicht: 20. März 2006

© 2006 Baghi et al.
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Background: Advanced and resectable larynx and hypopharynx squamous cell carcinomas are , in the vast majority of cases, treated by surgery and postoperative irradiation. Some institutions prefer to use irradiation and reserve radical surgery for salvage.The most frequent larynx preservation approach consists in the combination of irradiation and platin based chemotherapy. Induction chemotherapy followed by irradiation in good responders or by surgery in poor responders is the classic larynx conservation approach based on two large multicenter studies in the United states and Europe [1], [2]. Comparing with radical surgery followed by irradiation this strategy did not jeopardize survival and allowed larynx preservation in 50% to 66% of survivors. New aspects of this treatment form are the combination of induction chemotherapy followed by concomittant radiochemotherapy.

We perform a multicenter study which compares two treatment strategies: induction chemotherapy with cisplatin, 5-Fluouracil and docetaxel followed by radiochemotherapy with cisplatin in one arm with the same induction chemotherapy regimen followed by surgery and radiotherapy in the other arm.

Results: The first results with 60 patients with an advanced locally cancer of larynx or hypopharynx underwent a multimodal treatment with a triple chemotherapy regimen (3 cycles 75mg/qm taxotere, 100mg/qm cisplatin and 4000mg/qm 5-Fluouracil every three weeks) and the following chemoradiation (standard fracination with 70 Gy +100 mg/qm cisplatin every three weeks) show an overall response rate of 73% with a complete remission rate of 45%.

In summary, we predict that this form of multimodal treatment will accomplish a major change in prognosis and quality of life in patients with locally advanced SCC in head and neck and is a prognostic test for more aggressive treatment.


Forastiere AA, Goepfert H, Maor M, et al. Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer. N Engl J Med. 2003;349(22):2091-8.
Lefebvre JL, Chevalier D, Luboinski B, et al. Larynx preservation in pyriform sinus cancer: preliminary results of a European Organization for Research and Treatment of Cancer phase III trial. EORTC Head and Neck Cancer Cooperative Group. J Natl Cancer Inst. 1996;88(13):890-9.