gms | German Medical Science

27. Deutscher Krebskongress

Deutsche Krebsgesellschaft e. V.

22. - 26.03.2006, Berlin

Individualised Therapy in Geriatric Patients with Non-Hodgkin Lymphoma - Report of a Single Center

Meeting Abstract

  • corresponding author presenting/speaker Michael Schroeder - Medizinische Klinik I/Geriatrie, St.-Vincenz-Hospital, Katholisches Klinikum Duisburg, 47051 Duisburg, Deutschland
  • U. Greiff - Medizinische Klinik I/Geriatrie, St.-Vincenz-Hospital, Katholisches Klinikum Duisburg, 47051 Duisburg
  • T. Dastgir-Saadat - Medizinische Klinik I/Geriatrie, St.-Vincenz-Hospital, Katholisches Klinikum Duisburg, 47051 Duisburg
  • C. Noack - Medizinische Klinik I/Geriatrie, St.-Vincenz-Hospital, Katholisches Klinikum Duisburg, 47051 Duisburg
  • U. Schäfer - Medizinische Klinik I/Geriatrie, St.-Vincenz-Hospital, Katholisches Klinikum Duisburg, 47051 Duisburg

27. Deutscher Krebskongress. Berlin, 22.-26.03.2006. Düsseldorf, Köln: German Medical Science; 2006. DocPO115

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter: http://www.egms.de/de/meetings/dkk2006/06dkk225.shtml

Veröffentlicht: 20. März 2006

© 2006 Schroeder et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielf&aauml;ltigt, verbreitet und &oauml;ffentlich zug&aauml;nglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

The incidence of malignant lymphomas is increasing overproportionate especially in Europe, North America, and in elderly patients. Two third of the patients suffering from lymphoma are older than 65 years when disease is first diagnosed. In many guidelines age over 65 or 70 years or typical comorbidity of elderly patients is a risk factor for chemotherapy.

We report on geriatric lymphoma patients who were treated in a single center during 2003 to 2005. A total of 23 patients suffering from malignant lymphoma were treated in our hospital during the past 2 years.

Patient characteristics

Male: 8; female: 15

Age: 68-96 years, median: 81 years

Tumour characteristics

Malignancy grade: low grade: 5; intermediate: 4; high grade: 15

Newly diagnosed: 21/23 patients; relapse: 2/23 patients

1 malignant lymphoma was diagnosed as second malignancy; primary tumour: colorectal cancer

1 malignant lymphoma only affected the central nervous system

Therapy and follow up: Initially detailed geriatric assessment (general state of health, Barthel index, Charleston index, social activity) was performed prior to therapy as well as usual staging. After that a team defined the therapeutic strategy appropriate to the patient and according to the risk factors.

According to malignancy grade, spreading of lymphoma, and assessment different kinds of therapy were performed--intravenous treatment, oral chemotherapy or radiation (CHOP +/- Rituximab, R-B, COP, Ixoten). Two patients did not receive specific anti-cancer therapy but “best supportive care”. 13% of patients were enrolled in clinical studies. 14/23 patients are still alive, 8/23 patients are under active therapy at present, 6/23 patients are ongoing in complete remission (CR).

Summary: In view of the general circumstances and the geriatric assessment the anti-tumour therapy of geriatric patients suffering from malignant lymphoma is strongly indicated and promising.