gms | German Medical Science

57. Jahrestagung der Deutschen Gesellschaft für Neuropathologie und Neuroanatomie (DGNN)

Deutsche Gesellschaft für Neuropathologie und Neuroanatomie

12. - 15.09.2012, Erlangen

Banner: 57. Jahrestagung der Deutschen Gesellschaft für Neuropathologie und Neuroanatomie

еffect of chronic treatment with losartan on diurnal variations of behavior of wistar rats in kainate model of temporal lobe epilepsy

Meeting Abstract

  • presenting/speaker Natasha Ivanova - Bulgarian Academy of Science, Institute of Neurobiology, Sofia, Bulgaria
  • D. Pechlivanova - Bulgarian Academy of Science, Institute of Neurobiology, Sofia, Bulgaria
  • Milena Atanasova - MU – Pleven, Department of Biology, Pleven, Bulgaria
  • Jana Tchekalarova - Bulgarian Academy of Science, Institute of Neurobiology, Sofia, Bulgaria

Deutsche Gesellschaft für Neuropathologie und Neuroanatomie. 57th Annual Meeting of the German Society for Neuropathology and Neuroanatomy (DGNN). Erlangen, 12.-15.09.2012. Düsseldorf: German Medical Science GMS Publishing House; 2012. Doc12dgnnPP6.3

DOI: 10.3205/12dgnn114, URN: urn:nbn:de:0183-12dgnn1142

Veröffentlicht: 11. September 2012

© 2012 Ivanova et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielfältigt, verbreitet und öffentlich zugänglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

The selective AT1 receptor antagonist Losartan has been shown to have neuroprotective and anticonvulsant effect in acute seizure models [1]. The aim of the present study was to analyze the effect of chronic Losartan treatment during epileptogenesis on diurnal rhythms of behavior in Wistar rats in kainate (KA) model of temporal lobe of epilepsy (TLE). We have found that chronic exposure to Losartan exerts an antioxidant activity in Wistar rats. In kainate model of temporal lobe epilepsy (TLE) long-term losartan treatment started simultaneously with status epilepticus (SE). Losartan increased the latency for onset of spontaneous recurrent seizures in rats. The development of chronic epileptic stage was confirmed by the presence of spontaneous motor seizures (SMS) detected by video monitoring (24 h/3–5 month after SE). KA-treated epileptic Wistar rats demonstrated a hyperactivity and a reduced anxiety compared to their controls in open field test. Unlike controls, which demonstrated diurnal variations in locomotor activity, KA-treated rats exhibited abolished diurnal rhythms. Kainate-induced behavioral changes associated with motor activity and anxiety level were affected by Losartan during the chronic epileptic phase. Both control and KA groups treated with Losartan did not show diurnal variations in locomotor activity. However, Losartan potentiated the enhancement of locomotion in epileptic rats. Losartan caused a reversal of anxiety level close to controls. Taken together, it is suggested that Losartan is a potent antioxidant and is able to prevent some of deleterious consequences of epileptogenesis in Wistar rats.


References

1.
Pechlivanova D, Tchekalarova J, Stoynev A, et al. The effects of chronic losartan pretreatment on restraint stress-induced changes in motor activity, nociception and pentylenetetrazol generalized seizures in rats. Folia Med (Plovdiv). 2011 Apr-Jun;53(2):69-73.