Artikel
еffect of chronic treatment with losartan on diurnal variations of behavior of wistar rats in kainate model of temporal lobe epilepsy
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Veröffentlicht: | 11. September 2012 |
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Gliederung
Text
The selective AT1 receptor antagonist Losartan has been shown to have neuroprotective and anticonvulsant effect in acute seizure models [1]. The aim of the present study was to analyze the effect of chronic Losartan treatment during epileptogenesis on diurnal rhythms of behavior in Wistar rats in kainate (KA) model of temporal lobe of epilepsy (TLE). We have found that chronic exposure to Losartan exerts an antioxidant activity in Wistar rats. In kainate model of temporal lobe epilepsy (TLE) long-term losartan treatment started simultaneously with status epilepticus (SE). Losartan increased the latency for onset of spontaneous recurrent seizures in rats. The development of chronic epileptic stage was confirmed by the presence of spontaneous motor seizures (SMS) detected by video monitoring (24 h/3–5 month after SE). KA-treated epileptic Wistar rats demonstrated a hyperactivity and a reduced anxiety compared to their controls in open field test. Unlike controls, which demonstrated diurnal variations in locomotor activity, KA-treated rats exhibited abolished diurnal rhythms. Kainate-induced behavioral changes associated with motor activity and anxiety level were affected by Losartan during the chronic epileptic phase. Both control and KA groups treated with Losartan did not show diurnal variations in locomotor activity. However, Losartan potentiated the enhancement of locomotion in epileptic rats. Losartan caused a reversal of anxiety level close to controls. Taken together, it is suggested that Losartan is a potent antioxidant and is able to prevent some of deleterious consequences of epileptogenesis in Wistar rats.
References
- 1.
- Pechlivanova D, Tchekalarova J, Stoynev A, et al. The effects of chronic losartan pretreatment on restraint stress-induced changes in motor activity, nociception and pentylenetetrazol generalized seizures in rats. Folia Med (Plovdiv). 2011 Apr-Jun;53(2):69-73.