gms | German Medical Science

64. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

26. - 29. Mai 2013, Düsseldorf

Artikel

Artikel empfehlen

Hypocalcaemia as a prognostic factor of mortality in moderate and severe traumatic brain injury

Meeting Abstract

Suche in Medline nach

  • Juan Manuel Vinas-Ríos - Department of Neurosurgery, Evangelisches Krankenhaus Oldenburg‚ Germany
  • Martín Sánchez-Aguilar - Department of Epidemiology and Public Health. Faculty of Medicine, Universidad Autónoma de San Luís Potosí, México; Laboratory of Experimental Surgery. Faculty of Medicine, Universidad Autónoma de San Luís Potosí, México
  • José Juan Sánchez-Rodriguez - Department of Epidemiology and Public Health. Faculty of Medicine, Universidad Autónoma de San Luís Potosí, México
  • Daniel González-Aguirre - Department of Epidemiology and Public Health. Faculty of Medicine, Universidad Autónoma de San Luís Potosí, México
  • Rik Klarenbeek - Department of Neurosurgery, Evangelisches Krankenhaus Oldenburg‚ Germany
  • Christian Heinen - Department of Neurosurgery, Evangelisches Krankenhaus Oldenburg‚ Germany
  • Frerk Meyer - Department of Neurosurgery, Evangelisches Krankenhaus Oldenburg‚ Germany
  • Thomas Kretschmer - Department of Neurosurgery, Evangelisches Krankenhaus Oldenburg‚ Germany

Deutsche Gesellschaft für Neurochirurgie. 64. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC). Düsseldorf, 26.-29.05.2013. Düsseldorf: German Medical Science GMS Publishing House; 2013. DocMI.14.10

doi: 10.3205/13dgnc404, urn:nbn:de:0183-13dgnc4049

Veröffentlicht: 21. Mai 2013

© 2013 Vinas-Ríos et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielfältigt, verbreitet und öffentlich zugänglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.

Gliederung

Text

Objective: Our main objective was to evaluate whether serum hypocalcaemia (defined as < 2.1 mmol/L (8.5 mg/dL)) is a prognostic factor for mortality in the first 72 hours after moderate and severe TBI.

Method: We developed an ambispective comparative case-control study. We evaluated clinical profiles from included patients from January 2005 to July 2009 and we prospectively recruited additional patients for evaluation from August 2009 to July 2011. Patients were between 1 and 89 years old and had a Glasgow Coma Scale (GCS) of 3-12 points following TBI.

Results: Retrospectively (January 2005 to July 2009) we compiled data from 81 patients. Prospectively (August 2009 to July 2011) we recruited 41 patients with moderate and severe TBI that fulfilled the inclusion criteria. A total of 122 patients with a mean age of 21 years old (range: 1 to 89) were included. From the studied patients, 101 (82.27%) were of the male gender and 21 (17.21%) of female gender. One hundred and thirteen (92.73%) patients survived and 9 (7.37%) died. The demographic variables, clinical variables, basal pH levels, associated lesions, intubation days and number of days in the intensive care unit are shown in Table 1. In Table 2 are shown the chemistry variables and blood cellularity from day 0 and 3. In Table 3 are shown the hypocalcemia frequency in the study groups. We calculated an OR of 5.2 (IC 4.48 to 6.032) for hypocalcemia on day three, which was associated with death. The adjusted variables in the logistic regression final model were: serum calcium on day three (OR 3.5, IC 95% 1.12 to 13.61 p<0.028) and anisocoria (OR 8.24 IC 95% 1.3 to 67.35 p<0.019) obtaining an adjusted R2 of 0.22 (p<0.005).

Conclusions: As seen in our study, the serum levels of calcium on day three could be useful for the prediction of mortality in patients with moderate and severe TBI.