Artikel
Long-term follow-up of cortical language sites by navigated transcranial magnetic stimulation compared to repeated awake craniotomy
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Autoren
Veröffentlicht: | 21. Mai 2013 |
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Gliederung
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Objective: Repetitive navigated transcranial magnetic stimulation (rTMS) is increasingly used for mapping of human language areas. In order to increase its clinical impact, the evaluation of cortical plasticity in terms of language function seems to be a key application.
Method: Three patients with left-sided opercular glioblastoma multiforme (GBM) underwent rTMS language mapping and language mapping by awake surgery for resection of the initial and 7–11 months later for recurrent GBM. Results of rTMS and intraoperative mapping were compared using the cortical parcellation system (CPS).
Results: Left-sided language dominance and induction of clear speech errors were provoked during rTMS and during awake surgery. Consistency of the results of both methods was present in all cases and the plastic changes over time were present in one case.
Conclusions: This small series shows for the first time that language plasticity can be revealed by preoperative rTMS with an object naming task, even in recurrent gliomas.