gms | German Medical Science

63. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie (JNS)

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

13. - 16. Juni 2012, Leipzig

Nonlinear neuronal firing patterns of single unit activities of globus pallidus externus and internus in dystonia

Meeting Abstract

  • M. Alam - Department of Neurosurgery, Hannover Medical School, Hannover, Germany
  • J. Lim - Department of Neurosurgery, The Neuroscience Institute, Scott & White Hospitals and Texas A&M Health Science Center, Texas, U.S.A
  • M.K. Sanghera - Department of Neurosurgery, The Neuroscience Institute, Scott & White Hospitals and Texas A&M Health Science Center, Texas, U.S.A
  • H.H. Capelle - Department of Neurosurgery, Hannover Medical School, Hannover, Germany
  • H.E. Heissler - Department of Neurosurgery, Hannover Medical School, Hannover, Germany
  • J.K. Krauss - Department of Neurosurgery, Hannover Medical School, Hannover, Germany

Deutsche Gesellschaft für Neurochirurgie. Japanische Gesellschaft für Neurochirurgie. 63. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie (JNS). Leipzig, 13.-16.06.2012. Düsseldorf: German Medical Science GMS Publishing House; 2012. DocP 042

DOI: 10.3205/12dgnc429, URN: urn:nbn:de:0183-12dgnc4290

Veröffentlicht: 4. Juni 2012

© 2012 Alam et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielfältigt, verbreitet und öffentlich zugänglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

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Objective: The aim of this study was to evaluate the variability of non-linear neuronal discharge patterns between the external and internal segments of the globus pallidus (GPe and GPi) in patients with dystonia.

Methods: Twenty dystonia patients were studied during functional stereotactic neurosurgical operations for implantation of deep brain stimulation (DBS) electrodes. There were 11 men and 9 women, mean age at surgery was 44±3.7 years. Diagnosis was generalized dystonia (6 patients), cervical dystonia (8 patients) and segmental dystonia (6 patients). In 2 patients surgery was performed under general anaesthesia while 18 patients had local anaesthesia only without sedation or analgesic medication. Single-unit activity recordings in the GPi and GPe were obtained during routine microelectrode recording and mapping to delineate nuclear borders and to identify the sensorimotor subregions.

Results: Based on comparison of standard deviations, coefficient of variation and dispersion index, ISIs from cells recorded in the GPi were shorter and less variable than ISIs from GPe cells. By using approximate entropy (ApEn), a nonlinear feature of statistical analysis, it was demonstrated that the ApEn values in most cells of the GPe were lower than of those in the GPi. Our data indicate that in the majority of cells i.e. 18/22 (82%) in the GPi and 5/5 (100%) in the GPe for 1000 ISIs, raw ISIs have lower entropy values than those observed after resampling of the original series.

Conclusions: This study indicates non-linear temporal organization as a common feature of neuronal discharge probability distribution in both the GPe and GPi of patients with dystonia.