gms | German Medical Science

63. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie (JNS)

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

13. - 16. Juni 2012, Leipzig

Podoplanin expression influences survival in glioblastoma

Meeting Abstract

  • M. Guentchev - Department of Neurosurgery, Klinikum Idar-Oberstein, Idar-Oberstein, Germany
  • S. Natchev - Department of Neuropathology, St. Ivan Rilski Hospital, Sofia, Bulgaria
  • P. Birner - Comprehensive Cancer Center - CNS unit, Medical University Vienna, Vienna, Austria
  • J. Tüttenberg - Department of Neurosurgery, Klinikum Idar-Oberstein, Idar-Oberstein, Germany

Deutsche Gesellschaft für Neurochirurgie. Japanische Gesellschaft für Neurochirurgie. 63. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie (JNS). Leipzig, 13.-16.06.2012. Düsseldorf: German Medical Science GMS Publishing House; 2012. DocFR.01.09

DOI: 10.3205/12dgnc173, URN: urn:nbn:de:0183-12dgnc1732

Veröffentlicht: 4. Juni 2012

© 2012 Guentchev et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielfältigt, verbreitet und öffentlich zugänglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

Objective: Podoplanin is a type-I transmembrane glycoprotein. Several reports suggest a role of podoplanin in tissue development and repair as well as in carcinogenesis. Podoplanin is widely expressed in tumours of the CNS, including ependymal tumours, choroid plexus papillomas, meningeomas, pilocytic astrocytomas and glioblastomas. In malignant astrocytic tumours, increased expression of podoplanin correlated with higher histological tumour malignancy. No data on Podoplanin influencing survival in glioma have been published yet.

Methods: Here we immunohistochemically assessed podoplanin expression using a monoclonal antibody in formalin-fixed, paraffin-embedded specimens of 80 patients with supratentorial glioblastomas and 21 patients with supratentorial grade II and III gliomas. Cases were rated either as positive or negative.

Results: Podoplanin was expressed in 1/13 grade II gliomas, 2/8 grade III gliomas, and 54/80 glioblastomas. Patients with glioblastomas expressing podoplanin had significantly shorter overall survival than those without (p = 0.01, log rank test).

Conclusions: Our findings provide evidence that Podoplanin is linked with clinically more aggressive behaviour in glioblastomas and suggest that podoplanin inhibition could be considered as a possible therapeutic approach in malignant gliomas.