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62. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgen (PNCH)

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

07. - 11. Mai 2011, Hamburg

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Chronic deep brain stimulation of the entopeduncular nucleus or the centromedian-parafascicular complex in the rat 6-hydroxydopamine Parkinson model improves levodopa-induced dyskinesias

Meeting Abstract

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  • M. Alam - Klinik für Neurochirurgie, Medizinische Hochschule Hannover; Zentrum für Systemische Neurowissenschaften, Hannover
  • H.H. Capelle - Klinik für Neurochirurgie, Medizinische Hochschule Hannover; Zentrum für Systemische Neurowissenschaften, Hannover
  • K. Schwabe - Klinik für Neurochirurgie, Medizinische Hochschule Hannover; Zentrum für Systemische Neurowissenschaften, Hannover
  • J.K. Krauss - Klinik für Neurochirurgie, Medizinische Hochschule Hannover; Zentrum für Systemische Neurowissenschaften, Hannover

Deutsche Gesellschaft für Neurochirurgie. Polnische Gesellschaft für Neurochirurgen. 62. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgen (PNCH). Hamburg, 07.-11.05.2011. Düsseldorf: German Medical Science GMS Publishing House; 2011. DocMO.12.09

doi: 10.3205/11dgnc094, urn:nbn:de:0183-11dgnc0949

Veröffentlicht: 28. April 2011

© 2011 Alam et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielfältigt, verbreitet und öffentlich zugänglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.

Gliederung

Text

Objective: Deep brain stimulation (DBS) is used in Parkinson's disease (PD) to treat levodopa-induced dyskinesias and fluctuations. The subthalamic nucleus (STN) and the globus pallidus internus (GPi) have been the standard targets in men. More recently, the centermedian-parafascicular complex (CM-Pf) has also been discussed as a possible target for DBS. We studied the effects of chronic DBS of the CM-Pf and the entopeduncular nucleus (EPN, the rat equivalent to the human GPi) on levodopa-induced dyskinesias in the 6-hydroxydopamine (6-OHDA) rat model of PD.

Methods: Unilateral nigrostriatal lesions were induced by injection of 6-OHDA in the medial forebrain bundle of female Sprague-Dawley rats (n=14). Subsequently, these rats were rendered dyskinetic by regular intraperitoneal injections of levodopa. Ipsilateral to the lesion, bipolar electrodes for stimulation were implanted in the EPN and the CM-Pf. In addition, electrodes were implanted in the dorsolateral striatum for the recording of local field potentials (LFPs). After recovery, individual thresholds for side effects of stimulation were determined. Thereafter, EPN, CM-Pf or sham DBS was applied for five days (130Hz, 80µs) and the effects of DBS on levodopa-induced dyskinesias were assessed.

Results: Both EPN and CM-Pf DBS improved dyskinesias (one-way ANOVA followed by Tukey test, p < 0.05). LFP activity in the beta frequency band was reduced after the injection of levodopa (two-way ANOVA followed by Tukey test, p < 0.05), while EPN and CM-Pf stimulation had no effect on beta oscillations.

Conclusions: Our results show that DBS of the EPN and CM-Pf might be useful to treat dyskinesias. Furthermore, we could demonstrate that DBS of either target exerts its therapeutic effect in the 6-OHDA rat model independent from its effect on beta activity.