gms | German Medical Science

62. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgen (PNCH)

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

07. - 11. Mai 2011, Hamburg

A porcine model of hydrocephalus to evaluate a telemetric ICP device

Meeting Abstract

  • M.R. Weinzierl - Neurochirurgische Klinik und Poliklinik, Klinikum rechts der Isar, München
  • M.F. Oertel - Neurochirurgische Klinik, RWTH Aachen
  • I. Krause - Helmholtz Institut für Biomedizinische Technik, Aachen
  • S. Jetzki - Helmholtz Institut für Biomedizinische Technik, Aachen
  • S. Leonhardt - Helmholtz Institut für Biomedizinische Technik, Aachen

Deutsche Gesellschaft für Neurochirurgie. Polnische Gesellschaft für Neurochirurgen. 62. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgen (PNCH). Hamburg, 07.-11.05.2011. Düsseldorf: German Medical Science GMS Publishing House; 2011. DocMO.06.04

DOI: 10.3205/11dgnc032, URN: urn:nbn:de:0183-11dgnc0320

Veröffentlicht: 28. April 2011

© 2011 Weinzierl et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielfältigt, verbreitet und öffentlich zugänglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

Objective: Kaolin-induced hydrocephalus is a well-established small-animal model. To evaluate human implants in vivo, however, small-animal models are not sufficient. Assigning the experimental design to bigger animals is not always feasible since one has to keep in mind that species-dependent characteristics have to be considered. This study was performed to establish Kaolin-induced hydrocephalus in adult pigs. ICP-data and animal care are addressed in particular.

Methods: 10 male pigs weighing 60–70 kg were anesthetized and 10 mg/kg BW Kaolin was injected slowly into the cisterna magna. ICP was monitored using an electronic implant with a pressure sensor, a two-axis-acceleration sensor, a MSP430 microcontroller, a 433 MHz communication chip and a battery for power supply. Imaging studies has been performed preoperatively, at postoperative day 3 and in case of clinical decline. Serial sections were prepared for histopathological examination.

Results: Occlusive hydrocephalus developed 3 to 5 days after surgery. Within 24h after surgery animals demonstrated clinical signs of basal aseptic meningitis. After clinical improvement there was a slow deterioration until hydrocephalus was proven by CCT. B- and P-waves known from human ICP could be demonstrated during ICP monitoring. Slowly increasing ICP paralleled increasing ventricular size.

Conclusions: Kaolin-induced hydrocephalus is feasible in adult pigs. To avoid injuries in symptomatic animals the experimental design has to be adapted. Concerning the ICP data the obtained results indicate that ICP characteristics are comparable in pigs and humans.