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60. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
Joint Meeting mit den Benelux-Ländern und Bulgarien

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

24. - 27.05.2009, Münster

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Low-grade gliomas presenting with pharmaco-resistant epilepsy: a different subgroup of low-grade gliomas

Meeting Abstract

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  • K. Minkin - Department of Neurosurgery, University Hospital "St. Ivan Rilski", Sofia, Bulgaria
  • C. Tzekov - Department of Neurosurgery, University Hospital "St. Ivan Rilski", Sofia, Bulgaria
  • E. Naydenov - Department of Neurosurgery, University Hospital "St. Ivan Rilski", Sofia, Bulgaria
  • A. Bussarsky - Department of Neurosurgery, University Hospital "St. Ivan Rilski", Sofia, Bulgaria
  • V. Karakostov - Department of Neurosurgery, University Hospital "St. Ivan Rilski", Sofia, Bulgaria
  • M. Marinov - Department of Neurosurgery, University Hospital "St. Ivan Rilski", Sofia, Bulgaria
  • K. Romansky - Department of Neurosurgery, University Hospital "St. Ivan Rilski", Sofia, Bulgaria
  • V. Bussarsky - Department of Neurosurgery, University Hospital "St. Ivan Rilski", Sofia, Bulgaria

Deutsche Gesellschaft für Neurochirurgie. 60. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit den Benelux-Ländern und Bulgarien. Münster, 24.-27.05.2009. Düsseldorf: German Medical Science GMS Publishing House; 2009. DocMO.05-02

doi: 10.3205/09dgnc019, urn:nbn:de:0183-09dgnc0198

Veröffentlicht: 20. Mai 2009

© 2009 Minkin et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielfältigt, verbreitet und öffentlich zugänglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.

Gliederung

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Objective: Patients with low-grade gliomas have 5-year survival rates from 42 to 92%. Patients with pharmaco-resistant epilepsy (PRE) due to LGG usually have a mean preoperative history of epilepsy longer than 10 years and some authors reported a 10-year postoperative recurrence free survival rate of 100% regardless of the extent of surgery. The authors investigated the preoperative and postoperative history of patients with LGG presenting only with PRE.

Methods: One hundred five patients with PRE were operated on in the Department of Neurosurgery, University Hospital “St. Ivan Rilski”, Sofia between 1998–2007. Thirty-one patients were with PRE as the only presenting complaint of LGG.

Results: Age of seizure onset ranged from 2 to 53 years (mean 23 years) and age at the time of operation ranged from 5 to 60 years (mean 31 years). The average epilepsy duration was 8 years (from 1 to 26 years). Seven patients had history of pharmaco-resistant epilepsy longer than 10 years. Surgical treatment consisted of complete tumor resection in 20 patients and incomplete resection in 11 patients. Complete seizure control (Engel class I) was achieved in 66%. The mean follow-up was 5 years (from 1 to 9 years). Two patients presented tumor progression 5 years after surgery and were reoperated for high-grade glioma.

Conclusions: LGG appear as a heterogeneous group of tumors. Patients with LGG presenting with PRE have frequently a long preoperative and postoperative history without tumor progression. The different clinical behaviour of these lesions suggests different location, size, histopathological findings, immunohistochemistry and molecular biology.