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59. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
3. Joint Meeting mit der Italienischen Gesellschaft für Neurochirurgie (SINch)

Deutsche Gesellschaft für Neurochirurgie (DGNC) e. V.

01. - 04.06.2008, Würzburg

Chiari I malformation: What are the reasons for the presence or absence of syringomyelia?

Chiari-I-Malformation: Wann entwickelt sich eine Syringomyelie?

Meeting Abstract

Suche in Medline nach

  • corresponding author U.M. Mauer - Abteilung Neurochirurgie, Bundeswehrkrankenhaus Ulm, Ulm
  • C. Müller - Abteilung Neurochirurgie, Bundeswehrkrankenhaus Ulm, Ulm
  • L. Weselak - Abteilung Neurochirurgie, Bundeswehrkrankenhaus Ulm, Ulm
  • U. Kunz - Abteilung Neurochirurgie, Bundeswehrkrankenhaus Ulm, Ulm

Deutsche Gesellschaft für Neurochirurgie. Società Italiana di Neurochirurgia. 59. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC), 3. Joint Meeting mit der Italienischen Gesellschaft für Neurochirurgie (SINch). Würzburg, 01.-04.06.2008. Düsseldorf: German Medical Science GMS Publishing House; 2008. DocMI.04.04

Die elektronische Version dieses Artikels ist vollständig und ist verfügbar unter: http://www.egms.de/de/meetings/dgnc2008/08dgnc230.shtml

Veröffentlicht: 30. Mai 2008

© 2008 Mauer et al.
Dieser Artikel ist ein Open Access-Artikel und steht unter den Creative Commons Lizenzbedingungen (http://creativecommons.org/licenses/by-nc-nd/3.0/deed.de). Er darf vervielf&aauml;ltigt, verbreitet und &oauml;ffentlich zug&aauml;nglich gemacht werden, vorausgesetzt dass Autor und Quelle genannt werden.


Gliederung

Text

Objective: Chiari I malformation is associated with an obstruction of cerebrospinal fluid (CSF) flow at the foramen magnum. CSF flow can be visualised using dynamic phase-contrast magnetic resonance imaging (MRI). We conducted this study to investigate the presence or absence of syringomyelia in patients with Chiari I malformation.

Methods: Dynamic phase-contrast MRI of the entire central nervous system was used to investigate 90 patients with Chiari I malformation. There were 61 females and 29 males with a mean age of 39 years (median age: 40 years; range: 3-80 years). Syringomyelia was present in 59 patients (41 women, 18 men; average age: 44 years; median age: 47 years; range: 6-80 years) and absent in 31 patients (20 women, 11 men; mean age: 28 years; median age: 29 years; range: 3-65 years).

Results: A mean tonsillar descent of 13 mm was demonstrated in patients with syringomyelia (median descent: 11 mm; range: 5-38 mm) and 16 mm in patients without syringomyelia (median descent: 13 mm; range: 5-67 mm). There was no significant difference in tonsillar ectopia between patients with syringomyelia and patients without syringomyelia (p=0.19). It was interesting to note that the mean age of patients without syringomyelia was considerably lower than that of patients with syringomyelia. This difference was highly significant (p<0.0005). A comparison of CSF flow pulsation amplitudes between patients with and without syringomyelia revealed a highly significant difference between the two groups only in the CSF flow amplitudes in the ventral cervical subarachnoid space (p<0.005) and a significant difference in the region of the thoracic spinal canal (p<0.05).

Conclusions: Our results suggest that age and thus disease duration are major factors influencing the presence or absence of syringomyelia in patients with Chiari I malformation.